MYB0 myb domain protein 0 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MYB0
Official Full Name: myb domain protein 0
Primary source: TAIR:AT3G27920
Locus tag: AT3G27920
See related: Araport:AT3G27920
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATGL1; ATMYB0; GL1; GLABRA 1; myb domain protein 0; TRICHOME DIFFERENTIATION PROTEIN GL1
Summary: Encodes GL1, a Myb-like protein that is required for induction of trichome development. Interacts with JAZ and DELLA proteins to regulate trichome initiation.
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Genomic context

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See MYB0 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 3

Sequence:: Chromosome: 3; NC_003074.8 (10361790..10363607, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggested that the Serine 92 in the conserved [D/E]Lx2 [R/K]x3Lx6Lx3R amino acid signature of GL1 is not essential for the interaction of GL1 and GL3, but may play a role in the binding of GL1 to the promoters of its target genes.
Title: A single amino acid substitution in the R3 domain of GLABRA1 leads to inhibition of trichome formation in Arabidopsis without affecting its interaction with GLABRA3.
GL1 represses the activation of the TRY promoter by GL3 and TTG1, and TTG1 suppresses the activation of the CPC promoter by GL1 and GL3.
Title: TRANSPARENT TESTA GLABRA1 and GLABRA1 Compete for Binding to GLABRA3 in Arabidopsis.
Protein interaction analysis revealed that MYB82 physically interacts with GLABRA3. In addition, MYB82 and GL1 can form homodimers and heterodimers at R2R3-MYB domains, which may explain why their overexpression reduces trichome numbers.
Title: MYB82 functions in regulation of trichome development in Arabidopsis.
AtMYC1 protein is predominantly localised in the cytoplasm and can relocate GL1 from the nucleus into the cytoplasm.
Title: Mutual control of intracellular localisation of the patterning proteins AtMYC1, GL1 and TRY/CPC in Arabidopsis.
GL1 has qualitative and likely quantitative effects on trichome density in natural populations of Arabidopsis thaliana.
Title: Natural variation in GL1 and its effects on trichome density in Arabidopsis thaliana.
Impaired fatty acid/lipid flux is associated with a nonallelic GLABRA1 mutation which causes abnormal cuticle formation and impaired plant immunity.
Title: The glabra1 mutation affects cuticle formation and plant responses to microbes.
20 novel genes in the regulatory network involved in the trichome formation are the direct targets of GL3/GL1.
Title: A systems approach reveals regulatory circuitry for Arabidopsis trichome initiation by the GL3 and GL1 selectors.
DNA binding of GL1 and GL3 via their own DNA-binding domains to the promoter of GL2 is probably required for the activation of GL2 expression.
Title: Arabidopsis transient expression analysis reveals that activation of GLABRA2 may require concurrent binding of GLABRA1 and GLABRA3 to the promoter of GLABRA2.
Expression levels of GL1, MYB23, GL2 and TTG1 were reduced in shoots of sad2 mutants while expression levels of GL3 and ENHANCER OF GLABRA3 (EGL3) were enhanced.
Title: SAD2 in Arabidopsis functions in trichome initiation through mediating GL3 function and regulating GL1, TTG1 and GL2 expression.
Data show that GL1 associates with TRANSPARENT TESTA GLABRA1 in vivo, forming a complex.
Title: The TTG1-bHLH-MYB complex controls trichome cell fate and patterning through direct targeting of regulatory loci.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MASC_STS16086 (e-PCR)
- UniSTS:258847

NM_113708.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fruit development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gibberellic acid mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within jasmonic acid mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of trichome morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trichome differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trichome patterning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: myb domain protein 0

NP_189430.1

myb domain protein 0 (MYB0); CONTAINS InterPro DOMAIN/s: SANT, DNA-binding (InterPro:IPR001005), Homeodomain-like (InterPro:IPR009057), Myb, DNA-binding (InterPro:IPR014778), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930), Homeodomain-related (InterPro:IPR012287), Myb transcription factor (InterPro:IPR015495); BEST Arabidopsis thaliana protein match is: myb domain protein 23 (TAIR:AT5G40330.1); Has 9086 Blast hits to 8334 proteins in 551 species: Archae - 0; Bacteria - 0; Metazoa - 839; Fungi - 495; Plants - 5921; Viruses - 3; Other Eukaryotes - 1828 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

10361790..10363607 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_113708.2 → NP_189430.1 myb domain protein 0 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_189430.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P27900, Q39109, Q53YQ0, Q93V34, Q93VW0, Q93WP0, Q947R6, Q9LF81, Q9LF82, Q9ST42

UniProtKB/TrEMBL

A0A5S9XH33, I6P6H3, I6P6X8, I6P6Y4, I6P7C7

Conserved Domains (2) summary

smart00717
Location:69 → 116

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:69 → 114

Myb_DNA-binding; Myb-like DNA-binding domain