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    CBL3 calcineurin B-like 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828764, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CBL3
    Official Full Name
    calcineurin B-like 3
    Primary source
    TAIR:AT4G26570
    Locus tag
    AT4G26570
    See related
    Araport:AT4G26570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCBL3; calcineurin B-like 3; T15N24.20; T15N24_20
    Summary
    member of AtCBLs (Calcineurin B-like Calcium Sensor Proteins)
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    Genomic context

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    See CBL3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    9
    Sequence:
    Chromosome: 4; NC_003075.7 (13408383..13411177, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene FKBP-like peptidyl-prolyl cis-trans isomerase family protein Neighboring gene calcineurin B-like protein 7 Neighboring gene RING/U-box superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene oligopeptide transporter 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis calcium sensor calcineurin B-like 3 inhibits the 5'-methylthioadenosine nucleosidase in a calcium-dependent manner. Oh SI, et al. Plant Physiol, 2008 Dec. PMID 18945934, Free PMC Article
    2. Tonoplast calcium sensors CBL2 and CBL3 control plant growth and ion homeostasis through regulating V-ATPase activity in Arabidopsis. Tang RJ, et al. Cell Res, 2012 Dec. PMID 23184060, Free PMC Article
    3. The vacuolar calcium sensors CBL2 and CBL3 affect seed size and embryonic development in Arabidopsis thaliana. Eckert C, et al. Plant J, 2014 Apr. PMID 24479654
    4. Calcineurin B-Like Protein-Interacting Protein Kinase CIPK21 Regulates Osmotic and Salt Stress Responses in Arabidopsis. Pandey GK, et al. Plant Physiol, 2015 Sep. PMID 26198257, Free PMC Article
    5. Vacuolar CBL-CIPK12 Ca(2+)-sensor-kinase complexes are required for polarized pollen tube growth. Steinhorst L, et al. Curr Biol, 2015 Jun 1. PMID 25936548

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtMTAN2 associated exclusively with CBL3.
      Title: Calcineurin B-like 3 calcium sensor associates with and inhibits 5'-methylthioadenosine nucleosidase 2 in Arabidopsis.
    2. crucial regulator of vacuolar dynamics and polarized pollen tube growth
      Title: Vacuolar CBL-CIPK12 Ca(2+)-sensor-kinase complexes are required for polarized pollen tube growth.
    3. While single cbl2 or cbl3 mutants did not display discernable phenotypes, cbl2/cbl3 mutants exhibited defects in vegetative growth and were severely impaired in seed development and morphology.
      Title: The vacuolar calcium sensors CBL2 and CBL3 affect seed size and embryonic development in Arabidopsis thaliana.
    4. CBL3 and CIPK9 regulates potassium homeostasis under low potassium stress.
      Title: A protein kinase, calcineurin B-like protein-interacting protein Kinase9, interacts with calcium sensor calcineurin B-like Protein3 and regulates potassium homeostasis under low-potassium stress in Arabidopsis.
    5. The tonoplast-localized CBL3 is critical for plant development and ion homeostasis in plant cells, at least in part through regulation of vacuolar H+-ATPase activity in plants.
      Title: Tonoplast calcium sensors CBL2 and CBL3 control plant growth and ion homeostasis through regulating V-ATPase activity in Arabidopsis.
    6. CBL3-GFP exhibited dynamic patterns of subcellular localization, including several endomembrane compartments, the apical plasma membrane (PM), and cytoskeleton-like structures in pollen tubes.
      Title: A genome-wide functional characterization of Arabidopsis regulatory calcium sensors in pollen tubes.
    7. CBL3 and ATMTN1 interact only in the presence of Ca(2+).
      Title: The Arabidopsis calcium sensor calcineurin B-like 3 inhibits the 5'-methylthioadenosine nucleosidase in a calcium-dependent manner.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001341813.1
    NM_118791.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within detection of calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within potassium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plant-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calcineurin B-like 3
    NP_001320073.1
    • calcineurin B-like 3 (CBL3); FUNCTIONS IN: calcium ion binding; INVOLVED IN: detection of calcium ion; LOCATED IN: plasma membrane, vacuole, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Recoverin (InterPro:IPR001125), EF-HAND 2 (InterPro:IPR018249), Calcineurin B protein (InterPro:IPR015757), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048); BEST Arabidopsis thaliana protein match is: calcineurin B-like protein 2 (TAIR:AT5G55990.1); Has 7988 Blast hits to 7953 proteins in 833 species: Archae - 0; Bacteria - 10; Metazoa - 3891; Fungi - 1253; Plants - 1902; Viruses - 0; Other Eukaryotes - 932 (source: NCBI BLink).
    NP_194387.1
    • calcineurin B-like 3 (CBL3); FUNCTIONS IN: calcium ion binding; INVOLVED IN: detection of calcium ion; LOCATED IN: plasma membrane, vacuole, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Calcineurin B protein (InterPro:IPR015757), Recoverin (InterPro:IPR001125), EF-HAND 2 (InterPro:IPR018249), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand-like domain (InterPro:IPR011992); BEST Arabidopsis thaliana protein match is: calcineurin B-like protein 2 (TAIR:AT5G55990.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      13408383..13411177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118791.4 → NP_194387.1  calcineurin B-like 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194387.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81447, Q8LEM7
      UniProtKB/TrEMBL
      A0A178UCE4, A0A178V0S1, A0A5S9XW35
      Conserved Domains (1) summary
      COG5126
      Location:40 → 198
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    2. NM_001341813.1 → NP_001320073.1  calcineurin B-like 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UCE4
      Conserved Domains (1) summary
      cl25352
      Location:40 → 202
      EFh_PEF; The penta-EF hand (PEF) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LEM7.2

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