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    COP8 Proteasome component (PCI) domain protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834312, updated on 18-Sep-2024

    Summary

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    Official Symbol
    COP8
    Official Full Name
    Proteasome component (PCI) domain protein
    Primary source
    TAIR:AT5G42970
    Locus tag
    AT5G42970
    See related
    Araport:AT5G42970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATS4; CONSTITUTIVE PHOTOMORPHOGENIC 14; CONSTITUTIVE PHOTOMORPHOGENIC 8; COP14; COP9 SIGNALOSOME SUBUNIT 4; CSN4; EMB134; EMBRYO DEFECTIVE 134; FUS4; FUS8; FUSCA 4; FUSCA 8; MBD2.17; MBD2_17
    Summary
    encodes subunit 4 of COP9 signalosome complex. sequence is similar to a subunit of the 19S regulatory particle of the 26S proteasome. recessive mutation causes derepression of photomorphogenesis.
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    Genomic context

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    See COP8 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    13
    Sequence:
    Chromosome: 5; NC_003076.8 (17237153..17240816, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene outer envelope pore 24B-like protein Neighboring gene Polynucleotidyl transferase, ribonuclease H-like superfamily protein Neighboring gene thioredoxin 3 Neighboring gene ubiquitin-conjugating enzyme 18 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis COP8, COP10, and COP11 genes are involved in repression of photomorphogenic development in darkness. Wei N, et al. Plant Cell, 1994 May. PMID 8038603, Free PMC Article
    2. Auxin responses in mutants of the Arabidopsis CONSTITUTIVE PHOTOMORPHOGENIC9 signalosome. Dohmann EM, et al. Plant Physiol, 2008 Jul. PMID 18467458, Free PMC Article
    3. An alternative tandem affinity purification strategy applied to Arabidopsis protein complex isolation. Rubio V, et al. Plant J, 2005 Mar. PMID 15703063
    4. CSN1 N-terminal-dependent activity is required for Arabidopsis development but not for Rub1/Nedd8 deconjugation of cullins: a structure-function study of CSN1 subunit of COP9 signalosome. Wang X, et al. Mol Biol Cell, 2002 Feb. PMID 11854419, Free PMC Article
    5. Regulation of COP1 nuclear localization by the COP9 signalosome via direct interaction with CSN1. Wang X, et al. Plant J, 2009 May. PMID 19175768

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. downregulation of CSN4 in Arabidopsis and in tobacco cells leads to delayed G1/S transition comparable to that observed when TCTP is downregulated. Loss-of-function of AtTCTP leads to increased fraction of deneddylated CUL1, suggesting that AtTCTP interferes negatively with COP9 function. Similar defects in cell proliferation and CUL1 neddylation status were observed in Drosophila knockdown for dCSN4 or dTCTP
      Title: TCTP and CSN4 control cell cycle progression and development by regulating CULLIN1 neddylation in plants and animals.
    2. Data suggest that Arabidopsis csn mutants undergo DNA damage, which might be the cause of the delay in G2 cell cycle progression.
      Title: The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_123663.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of photomorphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within photomorphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein deneddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of COP9 signalosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of COP9 signalosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Proteasome component (PCI) domain protein
    NP_199111.1
    • CONSTITUTIVE PHOTOMORPHOGENIC 8 (COP8); FUNCTIONS IN: protein binding; INVOLVED IN: cullin deneddylation, negative regulation of photomorphogenesis, G2 phase of mitotic cell cycle, photomorphogenesis; LOCATED IN: signalosome; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Proteasome component (PCI) domain (InterPro:IPR000717); BEST Arabidopsis thaliana protein match is: regulatory particle non-ATPase subunit 5B (TAIR:AT5G64760.2); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      17237153..17240816 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123663.3 → NP_199111.1  Proteasome component (PCI) domain protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199111.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L5U0, Q9FMM1, Q9SW74
      UniProtKB/TrEMBL
      A0A178UIE2, A0A384KTP3, A0A7G2FE21, Q1H5B6
      Conserved Domains (2) summary
      COG5071
      Location:92 → 384
      RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:263 → 362
      PCI; PCI domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L5U0.2

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