AACT1 Thiolase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: AACT1
Official Full Name: Thiolase family protein
Primary source: TAIR:AT5G47720
Locus tag: AT5G47720
See related: Araport:AT5G47720
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: acetoacetyl-CoA thiolase 1; MCA23.4; MCA23_4
Summary: Encodes a functional acetoacetyl-CoA thiolase that is functionally redundant with AACT2. Loss-of-function mutants show no apparent growth phenotypes.
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Genomic context

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See AACT1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 14

Sequence:: Chromosome: 5; NC_003076.8 (19331547..19334427)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AACT1 and AACT2 exhibit differential spatial and temporal expression patterns. AACT1 null mutants do not show a morphological phenotype under normal and stress growth conditions.
Title: Reverse genetic characterization of two paralogous acetoacetyl CoA thiolase genes in Arabidopsis reveals their importance in plant growth and development.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001036951.2

Supported by ESTs:

NM_124146.3

Supported by ESTs:

NM_180819.3

Supported by ESTs:

NM_203171.2

Supported by ESTs:

NM_203172.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables acetyl-CoA C-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetyl-CoA C-acetyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in cytoplasm	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Thiolase family protein

NP_001032028.1

Thiolase family protein; FUNCTIONS IN: transferase activity, transferring acyl groups other than amino-acyl groups, acetyl-CoA C-acetyltransferase activity, catalytic activity; INVOLVED IN: metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Thiolase (InterPro:IPR002155), Thiolase, active site (InterPro:IPR020610), Thiolase, N-terminal (InterPro:IPR020616), Thiolase, conserved site (InterPro:IPR020613), Thiolase, C-terminal (InterPro:IPR020617), Thiolase-like, subgroup (InterPro:IPR016038), Thiolase-like (InterPro:IPR016039); BEST Arabidopsis thaliana protein match is: acetoacetyl-CoA thiolase 2 (TAIR:AT5G48230.2); Has 23291 Blast hits to 23276 proteins in 2315 species: Archae - 454; Bacteria - 14875; Metazoa - 988; Fungi - 698; Plants - 252; Viruses - 0; Other Eukaryotes - 6024 (source: NCBI BLink).

NP_199583.1

Thiolase family protein; FUNCTIONS IN: transferase activity, transferring acyl groups other than amino-acyl groups, acetyl-CoA C-acetyltransferase activity, catalytic activity; INVOLVED IN: metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Thiolase (InterPro:IPR002155), Thiolase-like (InterPro:IPR016039), Thiolase, active site (InterPro:IPR020610), Thiolase, N-terminal (InterPro:IPR020616), Thiolase, C-terminal (InterPro:IPR020617), Thiolase, conserved site (InterPro:IPR020613), Thiolase-like, subgroup (InterPro:IPR016038); BEST Arabidopsis thaliana protein match is: acetoacetyl-CoA thiolase 2 (TAIR:AT5G48230.2); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NP_851150.1

Thiolase family protein; FUNCTIONS IN: transferase activity, transferring acyl groups other than amino-acyl groups, acetyl-CoA C-acetyltransferase activity, catalytic activity; INVOLVED IN: metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Thiolase (InterPro:IPR002155), Thiolase, active site (InterPro:IPR020610), Thiolase, N-terminal (InterPro:IPR020616), Thiolase, conserved site (InterPro:IPR020613), Thiolase, C-terminal (InterPro:IPR020617), Thiolase-like, subgroup (InterPro:IPR016038), Thiolase-like (InterPro:IPR016039); BEST Arabidopsis thaliana protein match is: acetoacetyl-CoA thiolase 2 (TAIR:AT5G48230.2); Has 23084 Blast hits to 23069 proteins in 2286 species: Archae - 472; Bacteria - 14683; Metazoa - 981; Fungi - 680; Plants - 248; Viruses - 0; Other Eukaryotes - 6020 (source: NCBI BLink).

NP_974900.1

Thiolase family protein; FUNCTIONS IN: transferase activity, transferring acyl groups other than amino-acyl groups, acetyl-CoA C-acetyltransferase activity, catalytic activity; INVOLVED IN: metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Thiolase (InterPro:IPR002155), Thiolase, active site (InterPro:IPR020610), Thiolase, N-terminal (InterPro:IPR020616), Thiolase, conserved site (InterPro:IPR020613), Thiolase, C-terminal (InterPro:IPR020617), Thiolase-like, subgroup (InterPro:IPR016038), Thiolase-like (InterPro:IPR016039); BEST Arabidopsis thaliana protein match is: acetoacetyl-CoA thiolase 2 (TAIR:AT5G48230.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_974901.2

Thiolase family protein; FUNCTIONS IN: transferase activity, transferring acyl groups other than amino-acyl groups, acetyl-CoA C-acetyltransferase activity, catalytic activity; INVOLVED IN: metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Thiolase (InterPro:IPR002155), Thiolase, active site (InterPro:IPR020610), Thiolase, N-terminal (InterPro:IPR020616), Thiolase, conserved site (InterPro:IPR020613), Thiolase, C-terminal (InterPro:IPR020617), Thiolase-like, subgroup (InterPro:IPR016038), Thiolase-like (InterPro:IPR016039); BEST Arabidopsis thaliana protein match is: acetoacetyl-CoA thiolase 2 (TAIR:AT5G48230.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

19331547..19334427

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_203171.2 → NP_974900.1 Thiolase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974900.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UN67, A0A7G2FKX1

Conserved Domains (2) summary

PLN02644
Location:13 → 405

PLN02644; acetyl-CoA C-acetyltransferase

cd00751
Location:17 → 403

thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
NM_124146.3 → NP_199583.1 Thiolase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_199583.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q3E710, Q3E8F1, Q9FIK7

UniProtKB/TrEMBL

A0A178UN06, A0A384KT84, A0A7G2FL33, A1L4X1, Q3E8F0

Conserved Domains (1) summary

PLN02644
Location:13 → 406

PLN02644; acetyl-CoA C-acetyltransferase
NM_180819.3 → NP_851150.1 Thiolase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_851150.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UN67, A0A7G2FKX1

Conserved Domains (2) summary

PLN02644
Location:13 → 405

PLN02644; acetyl-CoA C-acetyltransferase

cd00751
Location:17 → 403

thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
NM_203172.4 → NP_974901.2 Thiolase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974901.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q3E710, Q3E8F1, Q9FIK7

UniProtKB/TrEMBL

A0A178UN06, A0A384KT84, A0A7G2FL33, A1L4X1, Q3E8F0

Conserved Domains (1) summary

PLN02644
Location:13 → 406

PLN02644; acetyl-CoA C-acetyltransferase
NM_001036951.2 → NP_001032028.1 Thiolase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001032028.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A7G2FKX1, F4JYM8

Conserved Domains (2) summary

PLN02644
Location:21 → 412

PLN02644; acetyl-CoA C-acetyltransferase

cd00751
Location:24 → 410

thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...