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    ASP2 aspartate aminotransferase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832075, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ASP2
    Official Full Name
    aspartate aminotransferase 2
    Primary source
    TAIR:AT5G19550
    Locus tag
    AT5G19550
    See related
    Araport:AT5G19550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AAT2; ASPARTATE AMINOTRANSFERASE; aspartate aminotransferase 2; ASPARTATE AMINOTRANSFERASE 2; ASPAT; CYTOPLASMIC ISOZYME 1; T20D1.70; T20D1_70
    Summary
    Nitrogen metabolism. Major cytosolic isoenzyme controlling aspartate biosynthesis in the light.
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    Genomic context

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    See ASP2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    12
    Sequence:
    Chromosome: 5; NC_003076.8 (6597971..6601971)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene mechanosensitive channel of small conductance-like 9 Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene thermosome subunit gamma Neighboring gene ROP uanine nucleotide exchange factor 10 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis mutants define an in vivo role for isoenzymes of aspartate aminotransferase in plant nitrogen assimilation. Schultz CJ, et al. Genetics, 1998 Jun. PMID 9611168, Free PMC Article
    2. Influence of over-expression of cytosolic aspartate aminotransferase on amino acid metabolism and defence responses against Botrytis cinerea infection in Arabidopsis thaliana. Brauc S, et al. J Plant Physiol, 2011 Oct 15. PMID 21676488
    3. The aspartate aminotransferase gene family of Arabidopsis encodes isoenzymes localized to three distinct subcellular compartments. Schultz CJ, et al. Plant J, 1995 Jan. PMID 7894512
    4. Recombinant expression, purification, and characterization of three isoenzymes of aspartate aminotransferase from Arabidopsis thaliana. Wilkie SE, et al. Protein Expr Purif, 1998 Apr. PMID 9535706
    5. root uv-b sensitive mutants are suppressed by specific mutations in ASPARTATE AMINOTRANSFERASE2 and by exogenous vitamin B6. Leasure CD, et al. Mol Plant, 2011 Jul. PMID 21511809, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transgenic lines with the highest Asp2 expression displayed more spreading lesions when infected with B. cinerea.
      Title: Influence of over-expression of cytosolic aspartate aminotransferase on amino acid metabolism and defence responses against Botrytis cinerea infection in Arabidopsis thaliana.
    2. Specific asp2 mutations partially suppresses the rus1 and rus2 mutant phenotype.
      Title: root uv-b sensitive mutants are suppressed by specific mutations in ASPARTATE AMINOTRANSFERASE2 and by exogenous vitamin B6.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_121960.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-aspartate:2-oxoglutarate aminotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-aspartate:2-oxoglutarate aminotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables copper ion binding HDA PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within aspartate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in aspartate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    involved_in glutamate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    NOT located_in Golgi apparatus RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type cell wall HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasmodesma HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    aspartate aminotransferase 2
    NP_197456.1
    • aspartate aminotransferase 2 (ASP2); FUNCTIONS IN: L-aspartate:2-oxoglutarate aminotransferase activity, copper ion binding; INVOLVED IN: nitrogen compound metabolic process; LOCATED IN: cytosol, cell wall, plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Aminotransferase, class I/classII (InterPro:IPR004839), Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aminotransferases, class-I, pyridoxal-phosphate-binding site (InterPro:IPR004838), Aspartate/other aminotransferase (InterPro:IPR000796), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421); BEST Arabidopsis thaliana protein match is: aspartate aminotransferase 3 (TAIR:AT5G11520.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      6597971..6601971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121960.5 → NP_197456.1  aspartate aminotransferase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197456.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P46645
      UniProtKB/TrEMBL
      A0A178UCN1, A0A384KI72, Q1EBW2
      Conserved Domains (1) summary
      PLN02397
      Location:1 → 403
      PLN02397; aspartate transaminase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46645.2

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