Ppp1r7 protein phosphatase 1, regulatory subunit 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppp1r7provided by MGI
Official Full Name: protein phosphatase 1, regulatory subunit 7provided by MGI
Primary source: MGI:MGI:1913635
See related: Ensembl:ENSMUSG00000026275 AllianceGenome:MGI:1913635
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SDS22; 2310014J01Rik
Summary: Predicted to enable protein phosphatase regulator activity. Acts upstream of or within chromosome segregation. Predicted to be located in chromosome. Orthologous to human PPP1R7 (protein phosphatase 1 regulatory subunit 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 10.9), CNS E11.5 (RPKM 10.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 D; 1 47.24 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (93271350..93295344)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (93343610..93367616)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The three regulators (PPP1R2, PPP1R7, and PPP1R11)share localization with PP1gamma2 in the head and the principal piece of sperm. We show that the association of inhibitors to PP1gamma2 changes during epididymal sperm maturation. In immotile caput epididymal sperm, PPP1R2 and PPP1R7 are not bound to PP1gamma2, whereas in motile caudal sperm, all three inhibitors are bound as heterodimers or heterotrimers.
Title: Regulators of the protein phosphatase PP1γ2, PPP1R2, PPP1R7, and PPP1R11 are involved in epididymal sperm maturation.
Ppp1r7 may play a central role in regulating the PP1 interactome by acting as a competitive molecular "sponge" of PP1c during heart failure progression.
Title: Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase regulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromosome segregation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein phosphatase 1 regulatory subunit 7

Names: protein phosphatase 1 regulatory subunit 22; protein phosphatase 1, regulatory (inhibitor) subunit 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023200.3 → NP_075689.1 protein phosphatase 1 regulatory subunit 7

See identical proteins and their annotated locations for NP_075689.1

Status: VALIDATED

Source sequence(s)

AC124669, AK031983

Consensus CDS

CCDS15187.1

UniProtKB/Swiss-Prot

Q3UM45, Q9CV31, Q9Z105

Related

ENSMUSP00000027494.5, ENSMUST00000027494.11

Conserved Domains (4) summary

smart00446
Location:337 → 355

LRRcap; occurring C-terminal to leucine-rich repeats

sd00033
Location:101 → 122

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:254 → 295

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:231 → 287

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

93271350..93295344

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011248057.4 → XP_011246359.1 protein phosphatase 1 regulatory subunit 7 isoform X1

Conserved Domains (3) summary

smart00446
Location:184 → 202

LRRcap; occurring C-terminal to leucine-rich repeats

sd00033
Location:14 → 35

LRR_RI; leucine-rich repeat [structural motif]

NF033189
Location:2 → 166

internalin_A; class 1 internalin InlA