Stam2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stam2provided by MGI
Official Full Name: signal transducing adaptor molecule (SH3 domain and ITAM motif) 2provided by MGI
Primary source: MGI:MGI:1929100
See related: Ensembl:ENSMUSG00000055371 AllianceGenome:MGI:1929100
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hbp; 1200004O12Rik; 5730456G07Rik
Summary: Predicted to enable phosphatidylinositol binding activity and ubiquitin binding activity. Predicted to be involved in signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in endocytic vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and skin. Orthologous to human STAM2 (signal transducing adaptor molecule 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 8.5), testis adult (RPKM 7.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C1.1; 2 30.41 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (52582213..52632212, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (52692206..52742149, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stam2 is expressed in the nervous tissue, heart, digestive and endocrine system during embryo development.
Title: Stam2 expression pattern during embryo development.
These results demonstrate that the STAMs are indispensably involved in T-cell development and survival in the thymus through the prevention of apoptosis but are dispensable for the proximal signaling of TCR and cytokine receptors.
Title: Signal-transducing adaptor molecules STAM1 and STAM2 are required for T-cell development and survival.
SH3 domains of STAM2 and Grb2 retain the moderate characteristics of recognizing their ligand proteins like other SH3 domains for signal protein binding
Title: Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain.
plays important role in the mammalian endosomal/vacuolar protein sorting pathway
Title: Effects of deficiencies of STAMs and Hrs, mammalian class E Vps proteins, on receptor downregulation.
STAM proteins function in a multivalent complex that sorts ubiquitinated proteins into the multivesicular body pathway.
Title: STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB145015 (e-PCR)
- UniSTS:185474

UniSTS:234396 (e-PCR)
- UniSTS:234396

NoName (e-PCR)
- UniSTS:234397

RH126285 (e-PCR)
- UniSTS:162993

AB012611 (e-PCR)
- UniSTS:163281

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: signal transducing adapter molecule 2

Names: Hrs binding protein; STAM-2; hrs-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418464.1 → NP_001405393.1 signal transducing adapter molecule 2 isoform b

Status: VALIDATED

Source sequence(s)

AL928960
NM_001418465.1 → NP_001405394.1 signal transducing adapter molecule 2 isoform b

Status: VALIDATED

Source sequence(s)

AL928960
NM_001418466.1 → NP_001405395.1 signal transducing adapter molecule 2 isoform c

Status: VALIDATED

Source sequence(s)

AL928960

Related

ENSMUSP00000121898.2, ENSMUST00000127316.8
NM_001418467.1 → NP_001405396.1 signal transducing adapter molecule 2 isoform d

Status: VALIDATED

Source sequence(s)

AL928960
NM_019667.3 → NP_062641.1 signal transducing adapter molecule 2 isoform a

See identical proteins and their annotated locations for NP_062641.1

Status: VALIDATED

Source sequence(s)

AL928960

Consensus CDS

CCDS16037.1

UniProtKB/Swiss-Prot

A2AU00, O88811, Q8C8Y4

UniProtKB/TrEMBL

Q3TGH8

Related

ENSMUSP00000099820.2, ENSMUST00000102759.8

Conserved Domains (4) summary

cd11963
Location:204 → 260

SH3_STAM2; Src homology 3 domain of Signal Transducing Adaptor Molecule 2

cd03568
Location:9 → 143

VHS_STAM; VHS domain family, STAM subfamily; members include STAM (Signal Transducing Adaptor Molecule), EAST (EGFR-associated protein with SH3 and TAM domains) and Hbp (Hrs-binding protein). Collectively, they are referred to as STAM. All STAMs have at their ...

pfam02809
Location:166 → 181

UIM; Ubiquitin interaction motif

pfam03127
Location:294 → 367

GAT; GAT domain