Aldh8a1 aldehyde dehydrogenase 8 family, member A1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aldh8a1provided by MGI
Official Full Name: aldehyde dehydrogenase 8 family, member A1provided by MGI
Primary source: MGI:MGI:2653900
See related: Ensembl:ENSMUSG00000037542 AllianceGenome:MGI:2653900
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Raldh4
Summary: Enables retinal dehydrogenase activity. Acts upstream of or within 9-cis-retinoic acid biosynthetic process. Predicted to be located in cytoplasm. Is expressed in cochlea; inner ear; inner ear vestibular component; liver; and liver lobe. Orthologous to human ALDH8A1 (aldehyde dehydrogenase 8 family member A1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver adult (RPKM 83.6), kidney adult (RPKM 72.6) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A3; 10 9.75 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (21253199..21272477)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (21377300..21396578)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kinetic characterization of RALDH3 and 4, providing their specificities for retinal isomer substrates.
Title: Kinetic characterization of recombinant mouse retinal dehydrogenase types 3 and 4 for retinal substrates.
RALDH4 molecular cloning, cellular expression, and activity in 9-cis-retinoic acid biosynthesis in intact cells
Title: Mouse retinal dehydrogenase 4 (RALDH4), molecular cloning, cellular expression, and activity in 9-cis-retinoic acid biosynthesis in intact cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Markers

Aldh8a1 (e-PCR), detects polymorphism
- UniSTS:525745

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aminomuconate-semialdehyde dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables retinal dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables retinal dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables retinal dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables retinal dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within 9-cis-retinoic acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in L-kynurenine catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retinal metabolic process	IC Inferred by Curator more info	PubMed
involved_in retinal metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinal metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in retinoic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinoic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 2-aminomuconic semialdehyde dehydrogenase

Names: aldehyde dehydrogenase family 8 member A1; retinal dehydrogenase 4; retinal dehydrogenase type 4

NP_848828.1

EC 1.2.1.32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.