Cacng6 calcium channel, voltage-dependent, gamma subunit 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cacng6provided by MGI
Official Full Name: calcium channel, voltage-dependent, gamma subunit 6provided by MGI
Primary source: MGI:MGI:1859168
See related: Ensembl:ENSMUSG00000078815 AllianceGenome:MGI:1859168
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310033H20Rik
Summary: Predicted to enable calcium channel regulator activity. Predicted to be involved in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel. Predicted to be part of L-type voltage-gated calcium channel complex. Is expressed in central nervous system; heart; and retina. Human ortholog(s) of this gene implicated in aspirin-induced respiratory disease. Orthologous to human CACNG6 (calcium voltage-gated channel auxiliary subunit gamma 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in mammary gland adult (RPKM 5.5), limb E14.5 (RPKM 2.1) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A1; 7 2.0 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (3472017..3484183)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (3423588..3435667)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonistrated that Cacng6 gene expression in mouse dorsal raphe nucleus
Title: Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

General gene information

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Markers

AW050150 (e-PCR)
- UniSTS:179512

NoName (e-PCR)
- UniSTS:488695

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables calcium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables calcium channel regulator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of L-type voltage-gated calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of L-type voltage-gated calcium channel complex	ISO Inferred from Sequence Orthology more info
part_of L-type voltage-gated calcium channel complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: voltage-dependent calcium channel gamma-6 subunit

Names: neuronal voltage-gated calcium channel gamma-6 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133183.2 → NP_573446.1 voltage-dependent calcium channel gamma-6 subunit

See identical proteins and their annotated locations for NP_573446.1

Status: VALIDATED

Source sequence(s)

AC217111

Consensus CDS

CCDS39726.1

UniProtKB/Swiss-Prot

Q8VHW3

UniProtKB/TrEMBL

Q14C42, Q14C43

Related

ENSMUSP00000138622.2, ENSMUST00000183200.8

Conserved Domains (1) summary

cl21598
Location:47 → 223

PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

3472017..3484183

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006540200.4 → XP_006540263.1 voltage-dependent calcium channel gamma-6 subunit isoform X1

See identical proteins and their annotated locations for XP_006540263.1

UniProtKB/TrEMBL

A0A0A0MQD3, Q14C43

Related

ENSMUSP00000104287.3, ENSMUST00000108647.3

Conserved Domains (1) summary

cl21598
Location:47 → 141

PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
XM_036153252.1 → XP_036009145.1 voltage-dependent calcium channel gamma-6 subunit isoform X2

Conserved Domains (1) summary

cl21598
Location:47 → 181

PMP22_Claudin; PMP-22/EMP/MP20/Claudin family