Fndc3a fibronectin type III domain containing 3A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fndc3aprovided by MGI
Official Full Name: fibronectin type III domain containing 3Aprovided by MGI
Primary source: MGI:MGI:1196463
See related: Ensembl:ENSMUSG00000033487 AllianceGenome:MGI:1196463
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: sys; Fndc3; D14Ertd453e; 1700094E19Rik; F730017H24Rik
Summary: Acts upstream of or within several processes, including Sertoli cell development; fertilization; and spermatid development. Located in acrosomal vesicle; cytosol; and vesicle membrane. Is expressed in brain; inner ear; limb; and submandibular gland primordium. Orthologous to human FNDC3A (fibronectin type III domain containing 3A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 15.1), placenta adult (RPKM 12.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D2; 14 37.62 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (72775388..72948141, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (72537948..72710701, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Models are presented for the function of FNDC3A in mediating spermatid-Sertoli adhesion during mouse spermatogenesis.
Title: FNDC3A is required for adhesion between spermatids and Sertoli cells.

Submit: New GeneRIF Correction

Phenotypes

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Associated conditions

Description	Tests
symplastic spermatids GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1) 1 citation
Transgenic (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237227

NoName (e-PCR)
- UniSTS:237228

C86600 (e-PCR)
- UniSTS:167136

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within Sertoli cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatid development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fibronectin type-III domain-containing protein 3A

Names: fibronectin domain-containing protein 3a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207636.3 → NP_997519.2 fibronectin type-III domain-containing protein 3A

See identical proteins and their annotated locations for NP_997519.2

Status: VALIDATED

Source sequence(s)

AC158981, AC165423, CT010579

Consensus CDS

CCDS27264.1

UniProtKB/Swiss-Prot

Q2VEY7, Q3T9K5, Q6ZQ15, Q811D3, Q8BME4, Q8BTM3, Q8BX90

UniProtKB/TrEMBL

F6TLV3

Related

ENSMUSP00000086411.6, ENSMUST00000089017.12

Conserved Domains (1) summary

cd00063
Location:371 → 462

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

72775388..72948141 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006519115.5 → XP_006519178.2 fibronectin type-III domain-containing protein 3A isoform X1

See identical proteins and their annotated locations for XP_006519178.2

UniProtKB/Swiss-Prot

Q2VEY7, Q3T9K5, Q6ZQ15, Q811D3, Q8BME4, Q8BTM3, Q8BX90

UniProtKB/TrEMBL

F6TLV3

Conserved Domains (1) summary

cd00063
Location:371 → 462

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_036158666.1 → XP_036014559.1 fibronectin type-III domain-containing protein 3A isoform X1

UniProtKB/Swiss-Prot

Q2VEY7, Q3T9K5, Q6ZQ15, Q811D3, Q8BME4, Q8BTM3, Q8BX90

UniProtKB/TrEMBL

F6TLV3

Conserved Domains (1) summary

cd00063
Location:371 → 462

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_030247858.2 → XP_030103718.1 fibronectin type-III domain-containing protein 3A isoform X4

UniProtKB/TrEMBL

F6TLV3

Conserved Domains (1) summary

cd00063
Location:307 → 398

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_006519116.5 → XP_006519179.1 fibronectin type-III domain-containing protein 3A isoform X1

See identical proteins and their annotated locations for XP_006519179.1

UniProtKB/Swiss-Prot

Q2VEY7, Q3T9K5, Q6ZQ15, Q811D3, Q8BME4, Q8BTM3, Q8BX90

UniProtKB/TrEMBL

F6TLV3

Conserved Domains (1) summary

cd00063
Location:371 → 462

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_030247857.2 → XP_030103717.1 fibronectin type-III domain-containing protein 3A isoform X1

UniProtKB/Swiss-Prot

Q2VEY7, Q3T9K5, Q6ZQ15, Q811D3, Q8BME4, Q8BTM3, Q8BX90

UniProtKB/TrEMBL

F6TLV3

Conserved Domains (1) summary

cd00063
Location:371 → 462

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_036158665.1 → XP_036014558.1 fibronectin type-III domain-containing protein 3A isoform X1

UniProtKB/Swiss-Prot

Q2VEY7, Q3T9K5, Q6ZQ15, Q811D3, Q8BME4, Q8BTM3, Q8BX90

UniProtKB/TrEMBL

F6TLV3

Conserved Domains (1) summary

cd00063
Location:371 → 462

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_017316055.3 → XP_017171544.1 fibronectin type-III domain-containing protein 3A isoform X2

UniProtKB/TrEMBL

F6TLV3

Conserved Domains (1) summary

cd00063
Location:348 → 439

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_006519118.5 → XP_006519181.1 fibronectin type-III domain-containing protein 3A isoform X3

UniProtKB/TrEMBL

F6TLV3

Related

ENSMUSP00000124218.2, ENSMUST00000162825.8

Conserved Domains (1) summary

cd00063
Location:315 → 406

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...