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    Nek4 NIMA (never in mitosis gene a)-related expressed kinase 4 [ Mus musculus (house mouse) ]

    Gene ID: 23955, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nek4provided by MGI
    Official Full Name
    NIMA (never in mitosis gene a)-related expressed kinase 4provided by MGI
    Primary source
    MGI:MGI:1344404
    See related
    Ensembl:ENSMUSG00000021918 AllianceGenome:MGI:1344404
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Stk2
    Summary
    Enables manganese ion binding activity and protein serine/threonine kinase activity. Involved in protein phosphorylation. Located in cytoplasm. Is expressed in seminiferous tubule; spermatid; spermatocyte; and testis. Orthologous to human NEK4 (NIMA related kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 7.7), CNS E11.5 (RPKM 2.9) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nek4 in Genome Data Viewer
    Location:
    14 B; 14 19.09 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30673334..30710778)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (30951377..30988821)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene inter-alpha trypsin inhibitor, heavy chain 1 Neighboring gene STARR-positive B cell enhancer ABC_E3106 Neighboring gene predicted gene, 41121 Neighboring gene STARR-seq mESC enhancer starr_36312 Neighboring gene signal peptidase complex subunit 1 homolog (S. cerevisiae) Neighboring gene glycosyltransferase 8 domain containing 1 Neighboring gene small nucleolar RNA, C/D box 69 Neighboring gene guanine nucleotide binding protein nucleolar 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NEK4 modulates circadian fluctuations of emotional behaviors and synaptogenesis in male mice. Yang ZH, et al. Nat Commun, 2024 Oct 24. PMID 39448584, Free PMC Article
    2. Nek4 status differentially alters sensitivity to distinct microtubule poisons. Doles J, et al. Cancer Res, 2010 Feb 1. PMID 20103636, Free PMC Article
    3. Activity and substrate specificity of the murine STK2 Serine/Threonine kinase that is structurally related to the mitotic regulator protein NIMA of Aspergillus nidulans. Hayashi K, et al. Biochem Biophys Res Commun, 1999 Oct 22. PMID 10529384
    4. Exploration of the cell-cycle genes found within the RIKEN FANTOM2 data set. Forrest AR, et al. Genome Res, 2003 Jun. PMID 12819135, Free PMC Article
    5. NIMA-related kinases: isolation and characterization of murine nek3 and nek4 cDNAs, and chromosomal localization of nek1, nek2 and nek3. Chen A, et al. Gene, 1999 Jun 24. PMID 10393247

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NEK4 modulates circadian fluctuations of emotional behaviors and synaptogenesis in male mice.
      Title: NEK4 modulates circadian fluctuations of emotional behaviors and synaptogenesis in male mice.
    2. Data show that after Taxol treatment, Nek4 promoted microtubule outgrowth, whereas Nek4 deficiency impaired G(2)-M arrest and decreased formation of mitotic-like asters.
      Title: Nek4 status differentially alters sensitivity to distinct microtubule poisons.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cellular senescence ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary plasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary rootlet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary transition zone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Nek4
    Names
    serine/threonine-protein kinase 2
    NP_001295257.1
    NP_035979.1
    XP_011243370.1
    XP_011243371.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308328.1 → NP_001295257.1  serine/threonine-protein kinase Nek4 isoform 2

      See identical proteins and their annotated locations for NP_001295257.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK078809, AK149584, BP762751
      Consensus CDS
      CCDS88612.1
      UniProtKB/Swiss-Prot
      O35673, Q9R1J1, Q9Z1J2
      UniProtKB/TrEMBL
      Q3UED6
      Related
      ENSMUSP00000154678.2, ENSMUST00000226551.2
      Conserved Domains (2) summary
      smart00220
      Location:6 → 261
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08223
      Location:5 → 261
      STKc_Nek4; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 4

    2. NM_011849.3 → NP_035979.1  serine/threonine-protein kinase Nek4 isoform 1

      See identical proteins and their annotated locations for NP_035979.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK078809, AK149584, BP762751, CN526970
      Consensus CDS
      CCDS26902.1
      UniProtKB/Swiss-Prot
      O35673, Q9R1J1, Q9Z1J2
      UniProtKB/TrEMBL
      Q6GTE9
      Related
      ENSMUSP00000154090.2, ENSMUST00000228328.2
      Conserved Domains (2) summary
      smart00220
      Location:6 → 261
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08223
      Location:5 → 261
      STKc_Nek4; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      30673334..30710778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245069.4 → XP_011243371.1  serine/threonine-protein kinase Nek4 isoform X2

      UniProtKB/Swiss-Prot
      O35673, Q9R1J1, Q9Z1J2
      Related
      ENSMUSP00000153710.2, ENSMUST00000226146.2
      Conserved Domains (1) summary
      cl21453
      Location:1 → 179
      PKc_like; Protein Kinases, catalytic domain

    2. XM_011245068.4 → XP_011243370.1  serine/threonine-protein kinase Nek4 isoform X1

      UniProtKB/TrEMBL
      F8WGA9
      Conserved Domains (1) summary
      cl21453
      Location:25 → 254
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1J2.1 GenPept UniProtKB/Swiss-Prot:Q9Z1J2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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