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    Csrp1 cysteine and glycine-rich protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 13007, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Csrp1provided by MGI
    Official Full Name
    cysteine and glycine-rich protein 1provided by MGI
    Primary source
    MGI:MGI:88549
    See related
    Ensembl:ENSMUSG00000026421 AllianceGenome:MGI:88549
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CRP1; Csrp
    Summary
    Predicted to enable actinin binding activity. Predicted to be a structural constituent of muscle. Predicted to be involved in muscle tissue development and sarcomere organization. Predicted to act upstream of or within actin cytoskeleton organization. Predicted to be located in actin cytoskeleton and nucleoplasm. Predicted to be active in Z disc and nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Orthologous to human CSRP1 (cysteine and glycine rich protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in bladder adult (RPKM 1668.6), stomach adult (RPKM 304.4) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Csrp1 in Genome Data Viewer
    Location:
    1 E4; 1 59.23 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (135614650..135679970)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (135720063..135752229)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene neuron navigator 1 Neighboring gene predicted gene, 32940 Neighboring gene predicted gene 4793 Neighboring gene STARR-seq mESC enhancer starr_02376 Neighboring gene STARR-seq mESC enhancer starr_02385 Neighboring gene predicted gene, 53478 Neighboring gene STARR-positive B cell enhancer ABC_E2561 Neighboring gene STARR-seq mESC enhancer starr_02387 Neighboring gene STARR-seq mESC enhancer starr_02388 Neighboring gene STARR-seq mESC enhancer starr_02389 Neighboring gene STARR-seq mESC enhancer starr_02392 Neighboring gene pleckstrin homology like domain, family A, member 3 Neighboring gene STARR-seq mESC enhancer starr_02394 Neighboring gene troponin I, skeletal, slow 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Psychosocial and behavioral predictors of inflammation in middle-aged and older adults: the Chicago health, aging, and social relations study. McDade TW, et al. Psychosom Med, 2006 May-Jun. PMID 16738067
    2. The LIM protein, CRP1, is a smooth muscle marker. Henderson JR, et al. Dev Dyn, 1999 Mar. PMID 10090149
    3. Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc. Wang X, et al. J Biol Chem, 1992 May 5. PMID 1374386
    4. Generation and characterization of Csrp1 enhancer-driven tissue-restricted Cre-recombinase mice. Snider P, et al. Genesis, 2008 Mar. PMID 18327771
    5. Loss of the serum response factor cofactor, cysteine-rich protein 1, attenuates neointima formation in the mouse. Lilly B, et al. Arterioscler Thromb Vasc Biol, 2010 Apr. PMID 20056913, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Csrp1 is not essential for normal smooth muscle differentiation during development, but may modulate the smooth muscle response to pathophysiological stress.
      Title: Loss of the serum response factor cofactor, cysteine-rich protein 1, attenuates neointima formation in the mouse.
    2. This ECsrp1(Cre) transgenic line should thus prove useful for genetic analysis of diverse aspects of cardiovascular morphogenesis.
      Title: Generation and characterization of Csrp1 enhancer-driven tissue-restricted Cre-recombinase mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actinin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of muscle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in muscle tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cysteine and glycine-rich protein 1
    Names
    CRP
    cysteine rich protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360782.2 → NP_001347711.1  cysteine and glycine-rich protein 1

      Status: VALIDATED

      Source sequence(s)
      AC162441
      Consensus CDS
      CCDS15320.1
      UniProtKB/Swiss-Prot
      P97315
      UniProtKB/TrEMBL
      Q4FJX4
      Related
      ENSMUSP00000095169.3, ENSMUST00000097561.9
      Conserved Domains (2) summary
      cd09403
      Location:119 → 172
      LIM2_CRP; The second LIM domain of Cysteine Rich Protein (CRP)
      cd09479
      Location:8 → 63
      LIM1_CRP1; The first LIM domain of Cysteine Rich Protein 1 (CRP1)

    2. NM_001420086.1 → NP_001407015.1  cysteine and glycine-rich protein 1

      Status: VALIDATED

      Source sequence(s)
      AC162441
      UniProtKB/Swiss-Prot
      P97315
      UniProtKB/TrEMBL
      Q4FJX4

    3. NM_001420087.1 → NP_001407016.1  cysteine and glycine-rich protein 1

      Status: VALIDATED

      Source sequence(s)
      AC162441
      UniProtKB/Swiss-Prot
      P97315
      UniProtKB/TrEMBL
      Q4FJX4

    4. NM_001420088.1 → NP_001407017.1  cysteine and glycine-rich protein 1

      Status: VALIDATED

      Source sequence(s)
      AC162441
      UniProtKB/Swiss-Prot
      P97315
      UniProtKB/TrEMBL
      Q4FJX4

    5. NM_001420089.1 → NP_001407018.1  cysteine and glycine-rich protein 1

      Status: VALIDATED

      Source sequence(s)
      AC162441
      UniProtKB/Swiss-Prot
      P97315
      UniProtKB/TrEMBL
      Q4FJX4

    6. NM_007791.7 → NP_031817.1  cysteine and glycine-rich protein 1

      See identical proteins and their annotated locations for NP_031817.1

      Status: VALIDATED

      Source sequence(s)
      AC162441
      Consensus CDS
      CCDS15320.1
      UniProtKB/Swiss-Prot
      P97315
      UniProtKB/TrEMBL
      Q4FJX4
      Related
      ENSMUSP00000027677.8, ENSMUST00000027677.8
      Conserved Domains (2) summary
      cd09403
      Location:119 → 172
      LIM2_CRP; The second LIM domain of Cysteine Rich Protein (CRP)
      cd09479
      Location:8 → 63
      LIM1_CRP1; The first LIM domain of Cysteine Rich Protein 1 (CRP1)

    RNA

    1. NR_153810.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC162441

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      135614650..135679970
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97315.3 GenPept UniProtKB/Swiss-Prot:P97315

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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