Pdgfrb platelet derived growth factor receptor, beta polypeptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pdgfrbprovided by MGI
Official Full Name: platelet derived growth factor receptor, beta polypeptideprovided by MGI
Primary source: MGI:MGI:97531
See related: Ensembl:ENSMUSG00000024620 AllianceGenome:MGI:97531
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pdgfr; CD140b; PDGFR-1
Summary: Enables platelet-derived growth factor receptor activity and signaling receptor binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; protein phosphorylation; and vasculature development. Acts upstream of or within several processes, including cellular response to hydrogen peroxide; response to ceramide; and ruffle assembly. Located in cell surface; cytoplasm; and ruffle. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Used to study several diseases, including autism spectrum disorder; basal ganglia calcification; infantile myofibromatosis; myeloproliferative neoplasm; and severe nonproliferative diabetic retinopathy. Human ortholog(s) of this gene implicated in basal ganglia calcification; glioblastoma; infantile myofibromatosis; myeloproliferative neoplasm (multiple); and renal cell carcinoma. Orthologous to human PDGFRB (platelet derived growth factor receptor beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in lung adult (RPKM 46.3), subcutaneous fat pad adult (RPKM 35.2) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E1; 18 34.41 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (61178194..61218139)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (61045127..61085067)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PTPN14 aggravates neointimal hyperplasia via boosting PDGFRbeta signaling in smooth muscle cells.
Title: PTPN14 aggravates neointimal hyperplasia via boosting PDGFRβ signaling in smooth muscle cells.
Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRbeta.
Title: Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRβ.
Elevated PDGF-BB from Bone Impairs Hippocampal Vasculature by Inducing PDGFRbeta Shedding from Pericytes.
Title: Elevated PDGF-BB from Bone Impairs Hippocampal Vasculature by Inducing PDGFRβ Shedding from Pericytes.
A Soluble Platelet-Derived Growth Factor Receptor-beta Originates via Pre-mRNA Splicing in the Healthy Brain and Is Upregulated during Hypoxia and Aging.
Title: A Soluble Platelet-Derived Growth Factor Receptor-β Originates via Pre-mRNA Splicing in the Healthy Brain and Is Upregulated during Hypoxia and Aging.
PDGFRbeta-positive cell-mediated post-stroke remodeling of fibronectin and laminin alpha2 for tissue repair and functional recovery.
Title: PDGFRβ-positive cell-mediated post-stroke remodeling of fibronectin and laminin α2 for tissue repair and functional recovery.
Dynamic expression of vascular endothelial growth factor (VEGF) and platelet-derived growth factor receptor beta (PDGFRbeta) in diabetic brain contributes to cognitive dysfunction.
Title: Dynamic expression of vascular endothelial growth factor (VEGF) and platelet-derived growth factor receptor beta (PDGFRβ) in diabetic brain contributes to cognitive dysfunction.
PDGF-D-PDGFRbeta signaling enhances IL-15-mediated human natural killer cell survival.
Title: PDGF-D-PDGFRβ signaling enhances IL-15-mediated human natural killer cell survival.
Correlation between mechanism of oxidized-low density lipoprotein-induced macrophage apoptosis and inhibition of target gene platelet derived growth factor receptor-beta expression by microRNA-9.
Title: Correlation between mechanism of oxidized-low density lipoprotein-induced macrophage apoptosis and inhibition of target gene platelet derived growth factor receptor-β expression by microRNA-9.
Skeletal stem cell fate defects caused by Pdgfrb activating mutation.
Title: Skeletal stem cell fate defects caused by Pdgfrb activating mutation.
YAP1/TEAD1 upregulate platelet-derived growth factor receptor beta to promote vascular smooth muscle cell proliferation and neointima formation.
Title: YAP1/TEAD1 upregulate platelet-derived growth factor receptor beta to promote vascular smooth muscle cell proliferation and neointima formation.

Submit: New GeneRIF Correction See all GeneRIFs (155)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (6) 1 citation
Gene trapped (1)
Targeted (26) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase binding	ISO Inferred from Sequence Orthology more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables platelet-derived growth factor beta-receptor activity	ISO Inferred from Sequence Orthology more info
enables platelet-derived growth factor beta-receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables platelet-derived growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables platelet-derived growth factor binding	ISO Inferred from Sequence Orthology more info
enables platelet-derived growth factor binding	TAS Traceable Author Statement more info	PubMed
enables platelet-derived growth factor receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables platelet-derived growth factor receptor activity	ISO Inferred from Sequence Orthology more info
enables platelet-derived growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor binding	ISO Inferred from Sequence Orthology more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adrenal gland development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in aorta morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in blood vessel development	IEP Inferred from Expression Pattern more info	PubMed
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cardiac myofibril assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cardiac vascular smooth muscle cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell migration involved in coronary angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration involved in vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to platelet-derived growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in embryonic organ development	IEP Inferred from Expression Pattern more info	PubMed
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within excretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in glycosaminoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
NOT involved_in hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lung growth	ISO Inferred from Sequence Orthology more info
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in metanephric glomerular capillary formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in metanephric glomerular mesangial cell proliferation involved in metanephros development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metanephric glomerular mesangium development	IEP Inferred from Expression Pattern more info	PubMed
involved_in metanephric mesenchymal cell migration	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylinositol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hepatic stellate cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic nuclear division	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of smooth muscle cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of actin cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to ceramide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retina vasculature development in camera-type eye	IGI Inferred from Genetic Interaction more info	PubMed
involved_in retina vasculature development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ruffle assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smooth muscle cell chemotaxis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within smooth muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tissue homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lysosomal lumen	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: platelet-derived growth factor receptor beta

Names: CD140 antigen-like family member B; PDGF beta chain; PDGF-R-beta; PDGFR-beta; beta platelet-derived growth factor receptor; beta-type platelet-derived growth factor receptor; platelet-derived growth factor receptor 1

NP_001139740.1

EC 2.7.10.1

NP_032835.2

EC 2.7.10.1

XP_011245158.1

EC 2.7.10.1

XP_030106221.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001146268.1 → NP_001139740.1 platelet-derived growth factor receptor beta isoform 1 precursor

See identical proteins and their annotated locations for NP_001139740.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK143247, BB291987, BY753644, X04367

Consensus CDS

CCDS50300.1

UniProtKB/TrEMBL

Q7TMR8

Related

ENSMUSP00000025522.5, ENSMUST00000025522.11

Conserved Domains (4) summary

pfam00047
Location:36 → 113

ig; Immunoglobulin domain

cd00096
Location:333 → 337

Ig; Ig strand B [structural motif]

cl11960
Location:313 → 414

Ig; Immunoglobulin domain

cl21453
Location:562 → 953

PKc_like; Protein Kinases, catalytic domain
NM_008809.2 → NP_032835.2 platelet-derived growth factor receptor beta isoform 2 precursor

See identical proteins and their annotated locations for NP_032835.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate in-frame splice site, compared to variant 1, that results in an isoform (2) that is one amino acid shorter than isoform 1.

Source sequence(s)

AK143247, BB291987, BY753644, X04367

UniProtKB/Swiss-Prot

E9QPE2, P05622

UniProtKB/TrEMBL

Q7TMR8

Related

ENSMUSP00000160025.1, ENSMUST00000249931.1

Conserved Domains (3) summary

pfam00047
Location:36 → 113

ig; Immunoglobulin domain

cl11960
Location:313 → 414

Ig; Immunoglobulin domain

cl21453
Location:561 → 952

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

61178194..61218139

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250361.2 → XP_030106221.1 platelet-derived growth factor receptor beta isoform X2

Conserved Domains (2) summary

pfam00047
Location:36 → 113

ig; Immunoglobulin domain

cl11960
Location:313 → 414

Ig; Immunoglobulin domain
XM_011246856.3 → XP_011245158.1 platelet-derived growth factor receptor beta isoform X1

Conserved Domains (2) summary

pfam00047
Location:36 → 113

ig; Immunoglobulin domain

cl11960
Location:313 → 414

Ig; Immunoglobulin domain