U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Htatip2 HIV-1 Tat interactive protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292935, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Htatip2provided by RGD
    Official Full Name
    HIV-1 Tat interactive protein 2provided by RGD
    Primary source
    RGD:1309941
    See related
    EnsemblRapid:ENSRNOG00000022189 AllianceGenome:RGD:1309941
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in import into nucleus and regulation of angiogenesis. Predicted to act upstream of or within positive regulation of programmed cell death; positive regulation of transcription by RNA polymerase II; and protein autophosphorylation. Predicted to be located in cytosol; mitochondrion; and nuclear envelope. Predicted to be active in cytoplasm. Orthologous to human HTATIP2 (HIV-1 Tat interactive protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 71.7), Kidney (RPKM 45.4) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Htatip2 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (108609424..108624810)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (99473411..99488632)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (105094272..105109459)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484893 Neighboring gene uncharacterized LOC102546796 Neighboring gene protein arginine methyltransferase 3 Neighboring gene U4 spliceosomal RNA Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 53

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Reduction of TIP30 in esophageal squamous cell carcinoma cells involves promoter methylation and microRNA-10b. Dong W, et al. Biochem Biophys Res Commun, 2014 Oct 31. PMID 25312779
    2. Metastasis suppressor CC3 inhibits angiogenic properties of tumor cells in vitro. NicAmhlaoibh R, et al. Oncogene, 2001 Jan 11. PMID 11313954
    3. Inhibition of nuclear import by the proapoptotic protein CC3. King FW, et al. Mol Cell Biol, 2004 Aug. PMID 15282309, Free PMC Article
    4. TIP30 has an intrinsic kinase activity required for up-regulation of a subset of apoptotic genes. Xiao H, et al. EMBO J, 2000 Mar 1. PMID 10698937, Free PMC Article
    5. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that TIP30 expression is regulated by promoter methylation and miR-10b in ESCC.
      Title: Reduction of TIP30 in esophageal squamous cell carcinoma cells involves promoter methylation and microRNA-10b.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    oxidoreductase HTATIP2
    Names
    HIV-1 tat interactive protein 2, homolog
    NP_001099733.1
    XP_006229311.1
    XP_006229312.1
    XP_006229313.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106263.2 → NP_001099733.1  oxidoreductase HTATIP2

      See identical proteins and their annotated locations for NP_001099733.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158803
      UniProtKB/TrEMBL
      A0A1L1WKF6, A0A8I6AEZ6, B0BNF8, G3V8Y4
      Related
      ENSRNOP00000092156.2, ENSRNOT00000117631.2
      Conserved Domains (2) summary
      cd05250
      Location:19 → 231
      CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
      COG0702
      Location:21 → 193
      YbjT; Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      108609424..108624810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229250.5 → XP_006229312.1  oxidoreductase HTATIP2 isoform X2

      See identical proteins and their annotated locations for XP_006229312.1

      UniProtKB/TrEMBL
      A0A1L1WKF6, A0A8I6AEZ6, B0BNF8, G3V8Y4
      Conserved Domains (2) summary
      cd05250
      Location:19 → 231
      CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
      COG0702
      Location:21 → 193
      YbjT; Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains [General function prediction only]

    2. XM_006229251.4 → XP_006229313.1  oxidoreductase HTATIP2 isoform X2

      See identical proteins and their annotated locations for XP_006229313.1

      UniProtKB/TrEMBL
      A0A1L1WKF6, A0A8I6AEZ6, B0BNF8, G3V8Y4
      Conserved Domains (2) summary
      cd05250
      Location:19 → 231
      CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
      COG0702
      Location:21 → 193
      YbjT; Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains [General function prediction only]

    3. XM_006229249.5 → XP_006229311.1  oxidoreductase HTATIP2 isoform X1

      See identical proteins and their annotated locations for XP_006229311.1

      UniProtKB/TrEMBL
      A0A0G2QC15, A6JBG2
      Related
      ENSRNOP00000030758.5, ENSRNOT00000036258.7
      Conserved Domains (2) summary
      cd05250
      Location:52 → 264
      CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
      COG0702
      Location:54 → 226
      YbjT; Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains [General function prediction only]
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools