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    Mkks MKKS centrosomal shuttling protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311456, updated on 27-Nov-2024

    Summary

    Official Symbol
    Mkksprovided by RGD
    Official Full Name
    MKKS centrosomal shuttling proteinprovided by RGD
    Primary source
    RGD:1308814
    See related
    EnsemblRapid:ENSRNOG00000006705 AllianceGenome:RGD:1308814
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    This gene encodes a protein which shares sequence similarity with other members of the type II chaperonin family. The encoded protein is a centrosome-shuttling protein and plays an important role in cytokinesis. This protein also interacts with other type II chaperonin members to form a complex known as the BBSome, which involves ciliary membrane biogenesis. This protein is encoded by a downstream open reading frame (dORF). Several upstream open reading frames (uORFs) have been identified, which repress the translation of the dORF, and two of which can encode small mitochondrial membrane proteins. [provided by RefSeq, Nov 2013]
    Expression
    Biased expression in Heart (RPKM 91.2), Brain (RPKM 90.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Mkks in Genome Data Viewer
    Location:
    3q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (144654563..144672831, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (124201877..124221142, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (129866542..129885213, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101685 Neighboring gene ribosomal protein lateral stalk subunit P1, pseudogene 2 Neighboring gene SLX4 interacting protein Neighboring gene uncharacterized LOC120101686 Neighboring gene uncharacterized LOC108350474

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Clone Names

    • MGC95109

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within artery smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    acts_upstream_of_or_within brain morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cartilage development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cerebral cortex development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chaperone-mediated protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within face development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hippocampus development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within leptin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of appetite by leptin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within non-motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within photoreceptor cell maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cilium beat frequency involved in ciliary motility ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to inositol IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to inositol ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to leptin ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sensory perception of smell ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within social behavior ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within spermatid development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within striatum development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within vasodilation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinociliary basal body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    molecular chaperone MKKS
    Names
    McKusick-Kaufman syndrome protein
    McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008353.2NP_001008354.1  molecular chaperone MKKS

      See identical proteins and their annotated locations for NP_001008354.1

      Status: REVIEWED

      Source sequence(s)
      BC083863, CB586701
      UniProtKB/TrEMBL
      A6HQK4, F7FCI3, Q5XI30
      Related
      ENSRNOP00000009540.3, ENSRNOT00000009540.7
      Conserved Domains (2) summary
      pfam00118
      Location:29569
      Cpn60_TCP1; TCP-1/cpn60 chaperonin family
      cl02777
      Location:32456
      chaperonin_like; chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      144654563..144672831 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)