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    Snap25 synaptosome associated protein 25 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25012, updated on 9-Dec-2024

    Summary

    Official Symbol
    Snap25provided by RGD
    Official Full Name
    synaptosome associated protein 25provided by RGD
    Primary source
    RGD:3728
    See related
    EnsemblRapid:ENSRNOG00000006037 AllianceGenome:RGD:3728
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SNAP-25B; SNAP-25a
    Summary
    Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein. It is essential for regulated exocytosis in neuronal cells. Alternative transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2012]
    Expression
    Restricted expression toward (RPKM 1950.9) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Snap25 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (144494579..144576449)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (124041898..124123761)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (129697408..129788417)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486160 Neighboring gene uncharacterized LOC108350472 Neighboring gene ankyrin repeat and EF-hand domain containing 1 Neighboring gene uncharacterized LOC134486161 Neighboring gene uncharacterized LOC120101685 Neighboring gene ribosomal protein lateral stalk subunit P1, pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC105414

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables SNAP receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables SNAP receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables SNARE binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables SNARE binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables SNARE binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables myosin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables syntaxin-1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables syntaxin-1 binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables syntaxin-1 binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables syntaxin-1 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables syntaxin-1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables voltage-gated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in SNARE complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in associative learning IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within associative learning ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in axonogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in calcium ion-regulated exocytosis of neurotransmitter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endosomal transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in exocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane fusion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hormone secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of insulin secretion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in presynaptic dense core vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in presynaptic dense core vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of establishment of protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synapse assembly IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in synaptic vesicle exocytosis EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in synaptic vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic vesicle exocytosis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in synaptic vesicle priming IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of BLOC-1 complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of BLOC-1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of BLOC-1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SNARE complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of SNARE complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axonal growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extrinsic component of presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in photoreceptor inner segment IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ribbon synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ribbon synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in somatodendritic compartment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in somatodendritic compartment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in terminal bouton HDA PubMed 
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    synaptosomal-associated protein 25
    Names
    SNAP-25
    SUP
    super protein
    synaptosomal-associated 25 kDa protein
    synaptosomal-associated protein, 25 kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270575.1NP_001257504.1  synaptosomal-associated protein 25 isoform a

      See identical proteins and their annotated locations for NP_001257504.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as a) encodes isoform a.
      Source sequence(s)
      BC087699, DY315301, FQ214162
      UniProtKB/TrEMBL
      F8WG75
      Related
      ENSRNOP00000007998.7, ENSRNOT00000007998.9
      Conserved Domains (3) summary
      cd15885
      Location:143201
      SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
      cd15894
      Location:1082
      SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
      pfam00835
      Location:91141
      SNAP-25; SNAP-25 family
    2. NM_001270576.1NP_001257505.1  synaptosomal-associated protein 25 isoform a

      See identical proteins and their annotated locations for NP_001257505.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon, compared to variant 1. Both variants 1 and 2 encode the same isoform a.
      Source sequence(s)
      BC087699, FM033263
      UniProtKB/TrEMBL
      F8WG75
      Related
      ENSRNOP00000008734.7, ENSRNOT00000008734.9
      Conserved Domains (3) summary
      cd15885
      Location:143201
      SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
      cd15894
      Location:1082
      SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
      pfam00835
      Location:91141
      SNAP-25; SNAP-25 family
    3. NM_030991.3NP_112253.1  synaptosomal-associated protein 25 isoform b

      See identical proteins and their annotated locations for NP_112253.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as b) has an alternate in-frame exon in the coding region, compared to variant 1. The resulting isoform (b) is of the same length, but has a distinct internal segment, compared to isoform a.
      Source sequence(s)
      BC087699, FQ214162
      UniProtKB/Swiss-Prot
      P60881
      UniProtKB/TrEMBL
      A6HQK1, A6HQK2
      Related
      ENSRNOP00000072612.2, ENSRNOT00000080581.3
      Conserved Domains (3) summary
      cd15885
      Location:143201
      SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
      cd15894
      Location:1082
      SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
      pfam00835
      Location:91141
      SNAP-25; SNAP-25 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      144494579..144576449
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283127.1XP_063139197.1  synaptosomal-associated protein 25 isoform X2

    2. XM_039104314.2XP_038960242.1  synaptosomal-associated protein 25 isoform X1

      UniProtKB/Swiss-Prot
      P60881
      UniProtKB/TrEMBL
      A6HQK1, A6HQK2
      Conserved Domains (3) summary
      cd15885
      Location:143201
      SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
      cd15894
      Location:1082
      SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
      pfam00835
      Location:91141
      SNAP-25; SNAP-25 family
    3. XM_063283128.1XP_063139198.1  synaptosomal-associated protein 25 isoform X3