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    Blm BLM RecQ like helicase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308755, updated on 3-Dec-2024

    Summary

    Official Symbol
    Blmprovided by RGD
    Official Full Name
    BLM RecQ like helicaseprovided by RGD
    Primary source
    RGD:1308810
    See related
    EnsemblRapid:ENSRNOG00000011213 AllianceGenome:RGD:1308810
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including ATP binding activity; DNA binding activity; and DNA helicase activity. Predicted to be involved in several processes, including DNA metabolic process; G-quadruplex DNA unwinding; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within several processes, including T cell differentiation; positive regulation of T cell proliferation; and regulation of DNA recombination. Predicted to be located in chromosome; cytosol; and nucleus. Predicted to be part of RecQ family helicase-topoisomerase III complex. Predicted to be active in chromosome; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in Bloom syndrome. Orthologous to human BLM (BLM RecQ like helicase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 115.2), Thymus (RPKM 77.2) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Blm in Genome Data Viewer
    Location:
    1q31
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (143819072..143905300, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (134409832..134496073, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (142246773..142332616, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553801 Neighboring gene furin (paired basic amino acid cleaving enzyme) Neighboring gene uncharacterized LOC134483745 Neighboring gene uncharacterized LOC108349447 Neighboring gene CREB regulated transcription coactivator 3 Neighboring gene uncharacterized LOC134483746 Neighboring gene chromobox protein homolog 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 3'-5' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 8-hydroxy-2'-deoxyguanosine DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP-dependent activity, acting on DNA ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA/DNA annealing activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables G-quadruplex DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables Y-form DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables bubble DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables forked DNA-dependent helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables four-way junction DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables four-way junction helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables four-way junction helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables telomeric D-loop binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables telomeric G-quadruplex DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DN4 thymocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA double-strand break processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA duplex unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G-quadruplex DNA unwinding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G-quadruplex DNA unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within alpha-beta T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of alpha-beta T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in cellular response to camptothecin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hydroxyurea ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chromosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of immature T cell proliferation in thymus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic G2 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of mitotic recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of mitotic recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mitotic recombination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of thymocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of alpha-beta T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of immature T cell proliferation in thymus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein complex oligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within replication-born double-strand break repair via sister chromatid exchange ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in resolution of DNA recombination intermediates ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to X-ray ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomere maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomeric D-loop disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RecQ family helicase-topoisomerase III complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lateral element ISO
    Inferred from Sequence Orthology
    more info
     
    located_in male germ cell nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in pronucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in replication fork ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    recQ-like DNA helicase BLM
    Names
    Bloom syndrome RecQ like helicase
    Bloom syndrome homolog
    Bloom syndrome, RecQ helicase-like
    NP_001413904.1
    XP_006229520.1
    XP_038956984.1
    XP_038956985.1
    XP_063118705.1
    XP_063118710.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001426975.1NP_001413904.1  recQ-like DNA helicase BLM

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      D3ZQW1
      Related
      ENSRNOP00000109578.1, ENSRNOT00000132954.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      143819072..143905300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101057.2XP_038956985.1  recQ-like DNA helicase BLM isoform X3

      UniProtKB/TrEMBL
      D3ZQW1
      Conserved Domains (5) summary
      smart00341
      Location:12011281
      HRDC; Helicase and RNase D C-terminal
      TIGR00614
      Location:6491132
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      pfam08072
      Location:362401
      BDHCT; BDHCT (NUC031) domain
      pfam16202
      Location:1356
      BLM_N; N-terminal region of Bloom syndrome protein
      pfam16204
      Location:415639
      BDHCT_assoc; BDHCT-box associated domain on Bloom syndrome protein
    2. XM_063262635.1XP_063118705.1  recQ-like DNA helicase BLM isoform X1

      UniProtKB/TrEMBL
      D3ZQW1
    3. XM_039101056.2XP_038956984.1  recQ-like DNA helicase BLM isoform X2

      UniProtKB/TrEMBL
      D3ZQW1
      Conserved Domains (5) summary
      smart00341
      Location:12091289
      HRDC; Helicase and RNase D C-terminal
      TIGR00614
      Location:6571140
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      pfam08072
      Location:370409
      BDHCT; BDHCT (NUC031) domain
      pfam16202
      Location:10364
      BLM_N; N-terminal region of Bloom syndrome protein
      pfam16204
      Location:423647
      BDHCT_assoc; BDHCT-box associated domain on Bloom syndrome protein
    4. XM_006229458.5XP_006229520.1  recQ-like DNA helicase BLM isoform X4

      UniProtKB/TrEMBL
      D3ZQW1
      Conserved Domains (9) summary
      smart00341
      Location:12101290
      HRDC; Helicase and RNase D C-terminal
      TIGR00614
      Location:6581141
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      smart00956
      Location:10771179
      RQC; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure
      cd00079
      Location:862993
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00270
      Location:670842
      DEAD; DEAD/DEAH box helicase
      pfam08072
      Location:371408
      BDHCT; BDHCT (NUC031) domain
      pfam16124
      Location:9981067
      RecQ_Zn_bind; RecQ zinc-binding
      pfam16202
      Location:10365
      BLM_N; N-terminal region of Bloom syndrome protein
      pfam16204
      Location:424648
      BDHCT_assoc; BDHCT-box associated domain on Bloom syndrome protein
    5. XM_063262640.1XP_063118710.1  recQ-like DNA helicase BLM isoform X5

      UniProtKB/TrEMBL
      D3ZQW1
      Related
      ENSRNOP00000015065.9, ENSRNOT00000015065.9

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107526.1: Suppressed sequence

      Description
      NM_001107526.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.