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    Yars1 tyrosyl-tRNA synthetase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313047, updated on 27-Nov-2024

    Summary

    Official Symbol
    Yars1provided by RGD
    Official Full Name
    tyrosyl-tRNA synthetase 1provided by RGD
    Primary source
    RGD:1307616
    See related
    EnsemblRapid:ENSRNOG00000007213 AllianceGenome:RGD:1307616
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Yars
    Summary
    Predicted to enable small molecule binding activity and tyrosine-tRNA ligase activity. Predicted to be involved in response to starvation and tyrosyl-tRNA aminoacylation. Predicted to be located in nuclear body. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate C. Orthologous to human YARS1 (tyrosyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 150.9), Liver (RPKM 148.3) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Yars1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (146820163..146848377)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (141535815..141564029)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (147375350..147403578)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 5 Neighboring gene S100P binding protein Neighboring gene U6 spliceosomal RNA Neighboring gene NHS like 3 Neighboring gene large ribosomal subunit protein uL23-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC112837

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables small molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small molecule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables tyrosine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tyrosine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables tyrosine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables tyrosine-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in response to starvation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tyrosyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tyrosyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    tyrosine--tRNA ligase, cytoplasmic
    Names
    tyrRS
    tyrosyl--tRNA ligase
    tyrosyl-tRNA synthetase, cytoplasmic
    NP_001020867.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025696.1NP_001020867.2  tyrosine--tRNA ligase, cytoplasmic

      See identical proteins and their annotated locations for NP_001020867.2

      Status: VALIDATED

      Source sequence(s)
      BC098795
      UniProtKB/Swiss-Prot
      Q4KM49
      UniProtKB/TrEMBL
      A6ISH9
      Related
      ENSRNOP00000107228.1, ENSRNOT00000129477.1
      Conserved Domains (3) summary
      cd02799
      Location:401504
      tRNA_bind_EMAP-II_like; tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae ...
      TIGR00234
      Location:45364
      tyrS; tyrosyl-tRNA synthetase
      cl00015
      Location:44364
      nt_trans; nucleotidyl transferase superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      146820163..146848377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)