Iscu iron-sulfur cluster assembly enzyme [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Iscuprovided by RGD
Official Full Name: iron-sulfur cluster assembly enzymeprovided by RGD
Primary source: RGD:1309562
See related: EnsemblRapid:ENSRNOG00000000701 AllianceGenome:RGD:1309562
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309562
Summary: Predicted to enable several functions, including 2 iron, 2 sulfur cluster binding activity; protein homodimerization activity; and transition metal ion binding activity. Predicted to be involved in several processes, including [2Fe-2S] cluster assembly; negative regulation of iron ion import across plasma membrane; and positive regulation of aconitate hydratase activity. Predicted to be located in cytosol and mitochondrion. Predicted to be part of mitochondrial [2Fe-2S] assembly complex. Predicted to be active in mitochondrial matrix. Orthologous to human ISCU (iron-sulfur cluster assembly enzyme). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 2068.6), Heart (RPKM 916.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (48512852..48518696, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (42852305..42858150, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (48621454..48627297, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-210-3p Inhibits Proliferation and Migration of C6 Cells by Targeting Iscu.
Title: MiR-210-3p Inhibits Proliferation and Migration of C6 Cells by Targeting Iscu.
miR-210 by downregulating ISCU and inducing mitochondrial dysfunction in neurons is a potent contributor of oxidative brain injury after neonatal Hypoxic-Ischemia.
Title: MicroRNA-210 Downregulates ISCU and Induces Mitochondrial Dysfunction and Neuronal Death in Neonatal Hypoxic-Ischemic Brain Injury.

Submit: New GeneRIF Correction

General gene information

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Markers

RH129226 (e-PCR)
- UniSTS:212534

RH129820 (e-PCR)
- UniSTS:212534

RH129298 (e-PCR)
- UniSTS:212605

RH129586 (e-PCR)
- UniSTS:212605

RH128101 (e-PCR)
- UniSTS:211409

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info
enables ferrous iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in [2Fe-2S] cluster assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of [4Fe-4S] cluster assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect [4Fe-4S] cluster assembly	ISO Inferred from Sequence Orthology more info
involved_in [4Fe-4S] cluster assembly	ISO Inferred from Sequence Orthology more info
involved_in intracellular iron ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in iron-sulfur cluster assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of iron ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of aconitate hydratase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial electron transport, NADH to ubiquinone	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of mitochondrial [2Fe-2S] assembly complex	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: iron-sulfur cluster assembly enzyme ISCU

Names: IscU iron-sulfur cluster scaffold homolog; iron-sulfur cluster assembly enzyme ISCU, mitochondrial; iron-sulfur cluster scaffold homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.