Itfg2 integrin alpha FG-GAP repeat containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itfg2provided by MGI
Official Full Name: integrin alpha FG-GAP repeat containing 2provided by MGI
Primary source: MGI:MGI:1915450
See related: Ensembl:ENSMUSG00000001518 AllianceGenome:MGI:1915450
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2700050P07Rik
Summary: Acts upstream of or within germinal center B cell differentiation. Located in cytosol and nucleoplasm. Orthologous to human ITFG2 (integrin alpha FG-GAP repeat containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 9.9), limb E14.5 (RPKM 8.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F3; 6 62.99 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (128386407..128401873, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (128409047..128424927, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results identify Itfg2 as a novel contributor to B cell differentiation and a negative regulator of the autoimmune response during lupus.
Title: Integrin-α FG-GAP repeat-containing protein 2 is critical for normal B cell differentiation and controls disease development in a lupus model.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)

General gene information

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Markers

AI646725 (e-PCR)
- UniSTS:179472

NoName (e-PCR)
- UniSTS:224369

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose starvation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within germinal center B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of TOR signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of KICSTOR complex	IBA Inferred from Biological aspect of Ancestor more info
part_of KICSTOR complex	ISO Inferred from Sequence Orthology more info
part_of KICSTOR complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: KICSTOR complex protein ITFG2

Names: integrin-alpha FG-GAP repeat-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133927.1 → NP_598688.1 KICSTOR complex protein ITFG2

See identical proteins and their annotated locations for NP_598688.1

Status: PROVISIONAL

Source sequence(s)

BC014833

Consensus CDS

CCDS20572.1

UniProtKB/Swiss-Prot

Q3UYJ5, Q8R148, Q91WI7

Related

ENSMUSP00000001559.9, ENSMUST00000001559.11

Conserved Domains (2) summary

pfam15907
Location:49 → 382

Itfg2; Integrin-alpha FG-GAP repeat-containing protein 2

cl24051
Location:22 → 53

BBS2_Mid; Ciliary BBSome complex subunit 2, middle region