Fyn Fyn proto-oncogene [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fynprovided by MGI
Official Full Name: Fyn proto-oncogeneprovided by MGI
Primary source: MGI:MGI:95602
See related: Ensembl:ENSMUSG00000019843 AllianceGenome:MGI:95602
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables several functions, including cytoskeletal protein binding activity; protein tyrosine kinase activity; and transmembrane transporter binding activity. Involved in several processes, including negative regulation of dendritic spine maintenance; positive regulation of tyrosine phosphorylation of STAT protein; and reelin-mediated signaling pathway. Acts upstream of or within several processes, including activated T cell proliferation; negative regulation of protein metabolic process; and nervous system development. Located in several cellular components, including actin filament; membrane raft; and postsynaptic density. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study skin disease and skin squamous cell carcinoma. Human ortholog(s) of this gene implicated in Alzheimer's disease and schizophrenia. Orthologous to human FYN (FYN proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 23.2), CNS E14 (RPKM 20.7) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B1; 10 20.51 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (39245735..39441377)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (39369743..39565381)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fat mass and obesity associated protein inhibits neuronal ferroptosis via the FYN/Drp1 axis and alleviate cerebral ischemia/reperfusion injury.
Title: Fat mass and obesity associated protein inhibits neuronal ferroptosis via the FYN/Drp1 axis and alleviate cerebral ischemia/reperfusion injury.
FYN regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization via its effect on Arp3 in the mouse testis.
Title: FYN regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization via its effect on Arp3 in the mouse testis.
DHF-7 Ameliorates Behavioral Disorders and White Matter Lesions by Regulating BDNF and Fyn in a Mouse Model of Schizophrenia Induced by Cuprizone and MK-801.
Title: DHF-7 Ameliorates Behavioral Disorders and White Matter Lesions by Regulating BDNF and Fyn in a Mouse Model of Schizophrenia Induced by Cuprizone and MK-801.
Fyn-kinase and caveolin-1 in the alveolar epithelial junctional adherence complex contribute to the early stages of pulmonary fibrosis.
Title: Fyn-kinase and caveolin-1 in the alveolar epithelial junctional adherence complex contribute to the early stages of pulmonary fibrosis.
Differential effects of the Src family tyrosine kinases Yes and Fyn on lipopolysaccharide-induced lung injury in ice.
Title: Differential effects of the Src family tyrosine kinases Yes and Fyn on lipopolysaccharide-induced lung injury in mice.
Disturbances in PP2A methylation and one-carbon metabolism compromise Fyn distribution, neuritogenesis, and APP regulation.
Title: Disturbances in PP2A methylation and one-carbon metabolism compromise Fyn distribution, neuritogenesis, and APP regulation.
Fyn specifically Regulates the activity of red cell glucose-6-phosphate-dehydrogenase.
Title: Fyn specifically Regulates the activity of red cell glucose-6-phosphate-dehydrogenase.
Nyap1 Regulates Multipolar-Bipolar Transition and Morphology of Migrating Neurons by Fyn Phosphorylation during Corticogenesis.
Title: Nyap1 Regulates Multipolar-Bipolar Transition and Morphology of Migrating Neurons by Fyn Phosphorylation during Corticogenesis.
Fyn depletion ameliorates tau(P301L)-induced neuropathology.
Title: Fyn depletion ameliorates tau(P301L)-induced neuropathology.
Fyn Kinase Controls Tau Aggregation In Vivo.
Title: Fyn Kinase Controls Tau Aggregation In Vivo.

Submit: New GeneRIF Correction See all GeneRIFs (191)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI448320 (e-PCR)
- UniSTS:165688

AW552119 (e-PCR)
- UniSTS:180026

PMC317175P1 (e-PCR)
- UniSTS:273078

18.MMHAP85FRF9.seq (e-PCR)
- UniSTS:159971

Fyn (e-PCR), detects polymorphism
- UniSTS:527352

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables CD4 receptor binding	ISO Inferred from Sequence Orthology more info
enables CD8 receptor binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables T cell receptor binding	ISO Inferred from Sequence Orthology more info
enables alpha-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables disordered domain specific binding	IEA Inferred from Electronic Annotation more info
enables disordered domain specific binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables ephrin receptor binding	IEA Inferred from Electronic Annotation more info
enables ephrin receptor binding	ISO Inferred from Sequence Orthology more info
enables growth factor receptor binding	IEA Inferred from Electronic Annotation more info
enables growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables peptide hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol 3-kinase binding	ISO Inferred from Sequence Orthology more info
enables phospholipase activator activity	IEA Inferred from Electronic Annotation more info
enables phospholipase activator activity	ISO Inferred from Sequence Orthology more info
enables phospholipase binding	IEA Inferred from Electronic Annotation more info
enables phospholipase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	TAS Traceable Author Statement more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables tau protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables type 5 metabotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within activated T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to L-glutamate	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amyloid-beta	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glycine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to platelet-derived growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to transforming growth factor beta stimulus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within forebrain development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within forebrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heart process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heart process	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myelination	TAS Traceable Author Statement more info	PubMed
involved_in natural killer cell activation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dendritic spine maintenance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hydrogen peroxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuron projection development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neuron projection development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein localization to nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein targeting to membrane	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in reelin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of calcium ion import across plasma membrane	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of cell shape	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of glutamate receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of peptidyl-tyrosine phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to amyloid-beta	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to ethanol	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to singlet oxygen	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in actin filament	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in glial cell projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perinuclear endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic density	IMP Inferred from Mutant Phenotype more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density, intracellular component	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tyrosine-protein kinase Fyn

Names: Src Kinase p59; p59-Fyn; proto-oncogene c-Fyn; proto-oncogene tyrosine-protein kinase Fyn

NP_001116364.1

EC 2.7.10.2

NP_001116365.1

EC 2.7.10.2

NP_032080.2

EC 2.7.10.2

XP_006512602.1

EC 2.7.10.2

XP_006512603.1

EC 2.7.10.2

XP_011241419.1

EC 2.7.10.2

XP_030100741.1

EC 2.7.10.2

XP_036011496.1

EC 2.7.10.2

XP_036011497.1

EC 2.7.10.2

XP_036011498.1

EC 2.7.10.2

XP_036011499.1

EC 2.7.10.2

XP_036011500.1

EC 2.7.10.2

XP_036011501.1

EC 2.7.10.2

XP_036011502.1

EC 2.7.10.2

XP_036011503.1

EC 2.7.10.2

XP_036011504.1

EC 2.7.10.2

XP_036011505.1

EC 2.7.10.2

XP_036011506.1

EC 2.7.10.2

XP_036011507.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122892.2 → NP_001116364.1 tyrosine-protein kinase Fyn isoform b

See identical proteins and their annotated locations for NP_001116364.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame exon in the coding region and differs in the 5' UTR compared to variant 1. It encodes an isoform (b) with a different and shorter internal segment compared to isoform a. Variants 2 and 3 both encode the same isoform (b).

Source sequence(s)

AC153422, AC153537

Consensus CDS

CCDS23788.1

UniProtKB/Swiss-Prot

P39688

Related

ENSMUSP00000115233.2, ENSMUST00000126486.8

Conserved Domains (3) summary

cd10368
Location:145 → 245

SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:258 → 531

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
NM_001122893.2 → NP_001116365.1 tyrosine-protein kinase Fyn isoform a

See identical proteins and their annotated locations for NP_001116365.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 4, and 5 all encode the same isoform (a).

Source sequence(s)

AC153422, AC153537

Consensus CDS

CCDS48538.1

UniProtKB/Swiss-Prot

P39688, Q3TAT3, Q3U0T5, Q8K2A3

Related

ENSMUSP00000097547.4, ENSMUST00000099967.10

Conserved Domains (3) summary

cd10418
Location:145 → 245

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:261 → 534

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
NM_001428463.1 → NP_001415392.1 tyrosine-protein kinase Fyn isoform a

Status: VALIDATED

Source sequence(s)

AC153422

UniProtKB/Swiss-Prot

P39688, Q3TAT3, Q3U0T5, Q8K2A3
NM_001428464.1 → NP_001415393.1 tyrosine-protein kinase Fyn isoform a

Status: VALIDATED

Source sequence(s)

AC153422, AC153537

UniProtKB/Swiss-Prot

P39688, Q3TAT3, Q3U0T5, Q8K2A3
NM_001428465.1 → NP_001415394.1 tyrosine-protein kinase Fyn isoform c

Status: VALIDATED

Source sequence(s)

AC153422, AC153537

UniProtKB/TrEMBL

D3YZ57
NM_008054.3 → NP_032080.2 tyrosine-protein kinase Fyn isoform b

See identical proteins and their annotated locations for NP_032080.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame exon in the coding region compared to variant 1. It encodes an isoform (b) with a different and shorter internal segment compared to isoform a. Variants 2 and 3 both encode the same isoform (b).

Source sequence(s)

AC153422, AC153537

Consensus CDS

CCDS23788.1

UniProtKB/Swiss-Prot

P39688

Related

ENSMUSP00000057707.7, ENSMUST00000063091.13

Conserved Domains (3) summary

cd10368
Location:145 → 245

SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:258 → 531

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

39245735..39441377

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155614.1 → XP_036011507.1 tyrosine-protein kinase Fyn isoform X6

Related

ENSMUSP00000118131.2, ENSMUST00000136659.2

Conserved Domains (3) summary

cd10368
Location:145 → 245

SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cl21453
Location:231 → 467

PKc_like; Protein Kinases, catalytic domain
XM_036155607.1 → XP_036011500.1 tyrosine-protein kinase Fyn isoform X3

UniProtKB/Swiss-Prot

P39688, Q3TAT3, Q3U0T5, Q8K2A3

Conserved Domains (3) summary

cd10418
Location:145 → 245

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:261 → 534

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_036155610.1 → XP_036011503.1 tyrosine-protein kinase Fyn isoform X4

Conserved Domains (3) summary

cd10368
Location:145 → 245

SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:258 → 531

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_036155603.1 → XP_036011496.1 tyrosine-protein kinase Fyn isoform X1

Conserved Domains (3) summary

cd10418
Location:184 → 284

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:124 → 179

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:300 → 573

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_036155606.1 → XP_036011499.1 tyrosine-protein kinase Fyn isoform X2

Conserved Domains (3) summary

cd10368
Location:184 → 284

SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn

cd12006
Location:124 → 179

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:297 → 570

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_036155613.1 → XP_036011506.1 tyrosine-protein kinase Fyn isoform X5

Conserved Domains (3) summary

cd10368
Location:184 → 284

SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn

cd12006
Location:124 → 179

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cl21453
Location:270 → 506

PKc_like; Protein Kinases, catalytic domain
XM_011243117.4 → XP_011241419.1 tyrosine-protein kinase Fyn isoform X3

See identical proteins and their annotated locations for XP_011241419.1

UniProtKB/Swiss-Prot

P39688, Q3TAT3, Q3U0T5, Q8K2A3

Conserved Domains (3) summary

cd10418
Location:145 → 245

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:261 → 534

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_036155612.1 → XP_036011505.1 tyrosine-protein kinase Fyn isoform X4

Conserved Domains (3) summary

cd10368
Location:145 → 245

SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:258 → 531

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_006512540.5 → XP_006512603.1 tyrosine-protein kinase Fyn isoform X3

Conserved Domains (3) summary

cd10418
Location:145 → 245

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:261 → 534

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_036155609.1 → XP_036011502.1 tyrosine-protein kinase Fyn isoform X3

UniProtKB/Swiss-Prot

P39688, Q3TAT3, Q3U0T5, Q8K2A3

Conserved Domains (3) summary

cd10418
Location:145 → 245

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:261 → 534

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_036155604.1 → XP_036011497.1 tyrosine-protein kinase Fyn isoform X1

Conserved Domains (3) summary

cd10418
Location:184 → 284

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:124 → 179

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:300 → 573

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_036155608.1 → XP_036011501.1 tyrosine-protein kinase Fyn isoform X3

UniProtKB/Swiss-Prot

P39688, Q3TAT3, Q3U0T5, Q8K2A3

Conserved Domains (3) summary

cd10418
Location:145 → 245

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:261 → 534

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_030244881.2 → XP_030100741.1 tyrosine-protein kinase Fyn isoform X1

Conserved Domains (3) summary

cd10418
Location:184 → 284

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:124 → 179

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:300 → 573

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_006512539.5 → XP_006512602.1 tyrosine-protein kinase Fyn isoform X3

Conserved Domains (3) summary

cd10418
Location:145 → 245

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:261 → 534

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_036155611.1 → XP_036011504.1 tyrosine-protein kinase Fyn isoform X4

Related

ENSMUSP00000117111.2, ENSMUST00000135242.8

Conserved Domains (3) summary

cd10368
Location:145 → 245

SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:258 → 531

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_036155605.1 → XP_036011498.1 tyrosine-protein kinase Fyn isoform X1

Conserved Domains (3) summary

cd10418
Location:184 → 284

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:124 → 179

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:300 → 573

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn