Rilpl2 Rab interacting lysosomal protein-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rilpl2provided by MGI
Official Full Name: Rab interacting lysosomal protein-like 2provided by MGI
Primary source: MGI:MGI:1933112
See related: Ensembl:ENSMUSG00000029401 AllianceGenome:MGI:1933112
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable dynein light intermediate chain binding activity; identical protein binding activity; and small GTPase binding activity. Involved in epithelial cell morphogenesis and protein transport from ciliary membrane to plasma membrane. Located in centrosome and cilium. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Orthologous to human RILPL2 (Rab interacting lysosomal protein like 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 19.9), spleen adult (RPKM 17.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 63.6 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (124601328..124616298, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (124463265..124478235, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

propose that Rab36 stimulates RILPL2 to interact with the myosin-5a globular tail domain (GTD); this interaction then induces exposure of the melanophilin-binding site in the GTD, enabling melanophilin to interact with the GTD and activate myosin-5a motor activity
Title: The cargo adaptor proteins RILPL2 and melanophilin co-regulate myosin-5a motor activity.
The Rilp-like proteins Rilpl1 and Rilpl2 regulate ciliary membrane content by promoting protein removal from the primary cilium.
Title: The Rilp-like proteins Rilpl1 and Rilpl2 regulate ciliary membrane content.
These data represent a novel mechanism linking RILPL2, the motor protein MyoVa and Rac1 with neuronal structure and function.
Title: Myosin-Va-interacting protein, RILPL2, controls cell shape and neuronal morphogenesis via Rac signaling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dynein light intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport from ciliary membrane to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RILP-like protein 2

Names: rab-interacting lysosomal-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030259.1 → NP_084535.1 RILP-like protein 2

See identical proteins and their annotated locations for NP_084535.1

Status: PROVISIONAL

Source sequence(s)

BC003324

Consensus CDS

CCDS19676.1

UniProtKB/Swiss-Prot

Q3TB73, Q99LE1

Related

ENSMUSP00000031347.8, ENSMUST00000031347.8

Conserved Domains (2) summary

cd14445
Location:18 → 95

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

pfam11461
Location:124 → 172

RILP; Rab interacting lysosomal protein