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    Catsper4 cation channel, sperm associated 4 [ Mus musculus (house mouse) ]

    Gene ID: 329954, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Catsper4provided by MGI
    Official Full Name
    cation channel, sperm associated 4provided by MGI
    Primary source
    MGI:MGI:3043288
    See related
    Ensembl:ENSMUSG00000048003 AllianceGenome:MGI:3043288
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933412L05
    Summary
    Enables voltage-gated calcium channel activity. Acts upstream of or within several processes, including flagellated sperm motility; sodium ion transport; and sperm capacitation. Located in acrosomal vesicle and sperm principal piece. Part of CatSper complex. Orthologous to human CATSPER4 (cation channel sperm associated 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 45.5) See more
    Orthologs
    human all
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    Genomic context

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    See Catsper4 in Genome Data Viewer
    Location:
    4 D2.3; 4 66.5 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (133939276..133954743, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (134211965..134227431, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene centrosomal protein 85 Neighboring gene STARR-positive B cell enhancer mm9_chr4:133715471-133715771 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:133742713-133742822 Neighboring gene STARR-positive B cell enhancer ABC_E843 Neighboring gene zona pellucida like domain containing 2 Neighboring gene connector enhancer of kinase suppressor of Ras 1 Neighboring gene STARR-positive B cell enhancer ABC_E7997 Neighboring gene Zfp593 opposite strand Neighboring gene zinc finger protein 593

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse. Jin J, et al. Biol Reprod, 2007 Jul. PMID 17344468
    2. CatSper genes expression, semen characteristics and histology of testes in the contusive spinal cord-injured mice model. Rezaian J, et al. Spinal Cord, 2009 Jan. PMID 18607386
    3. CATSPER channel-mediated Ca2+ entry into mouse sperm triggers a tail-to-head propagation. Xia J, et al. Biol Reprod, 2007 Sep. PMID 17554080
    4. Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis. Lobley A, et al. Reprod Biol Endocrinol, 2003 Aug 1. PMID 12932298, Free PMC Article
    5. Catsper3 and catsper4 encode two cation channel-like proteins exclusively expressed in the testis. Jin JL, et al. Biol Reprod, 2005 Dec. PMID 16107607

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that spinal cord injury doesn't significantly change the expression of CatSpers 4.
      Title: CatSper genes expression, semen characteristics and histology of testes in the contusive spinal cord-injured mice model.
    2. Catsper3 and Catsper4 knockout male mice are completely infertile due to a quick loss of motility and a lack of hyperactivated motility under capacitating conditions.
      Title: Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse.
    3. Catsper4 has a single channel-forming domain, a pore-loop with the consensus sequence TxDxW, & a coiled-coil protein-protein interaction domain in the C-terminal tail. CatSpers 1,2,3 & 4 may interact directly or indirectly to form a functional tetramer.
      Title: Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis.
    4. CATSPER4 is a cation-channel protein and has role in acrosome reaction and male fertility
      Title: Catsper3 and catsper4 encode two cation channel-like proteins exclusively expressed in the testis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124305, MGC124306

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium-activated cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in flagellated sperm motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sodium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm capacitation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sperm capacitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CatSper complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CatSper complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in sperm principal piece IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm principal piece IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cation channel sperm-associated protein 4
    Names
    cation channel of sperm 4
    channel, sperm associated 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130030.1 → NP_001123502.1  cation channel sperm-associated protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001123502.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) is missing 2 contiguous internal coding exons compared to variant 1, however, it maintains the reading frame, and encodes a shorter isoform (2) that is lacking a 73 aa internal segment compared to isoform 1.
      Source sequence(s)
      AK077145, BY104668, CR513858, EU781511
      Consensus CDS
      CCDS51324.1
      UniProtKB/TrEMBL
      B3VNK5
      Related
      ENSMUSP00000131094.2, ENSMUST00000169381.8
      Conserved Domains (2) summary
      pfam00520
      Location:126 → 216
      Ion_trans; Ion transport protein
      cl00567
      Location:101 → 201
      Colicin_V; Colicin V production protein

    2. NM_177866.4 → NP_808534.1  cation channel sperm-associated protein 4 isoform 1

      See identical proteins and their annotated locations for NP_808534.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK077145, BY104668, CR513858
      Consensus CDS
      CCDS18766.1
      UniProtKB/Swiss-Prot
      A2A9K6, Q8BVN3
      Related
      ENSMUSP00000051694.4, ENSMUST00000055892.10
      Conserved Domains (1) summary
      pfam00520
      Location:81 → 289
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      133939276..133954743 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164199.1 → XP_036020092.1  cation channel sperm-associated protein 4 isoform X1

      Conserved Domains (1) summary
      pfam00520
      Location:81 → 289
      Ion_trans; Ion transport protein

    2. XM_011250280.3 → XP_011248582.1  cation channel sperm-associated protein 4 isoform X2

      Conserved Domains (1) summary
      pfam00520
      Location:81 → 243
      Ion_trans; Ion transport protein

    RNA

    1. XR_004941926.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BVN3.1 GenPept UniProtKB/Swiss-Prot:Q8BVN3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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