Htr5b 5-hydroxytryptamine (serotonin) receptor 5B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Htr5bprovided by MGI
Official Full Name: 5-hydroxytryptamine (serotonin) receptor 5Bprovided by MGI
Primary source: MGI:MGI:96284
See related: Ensembl:ENSMUSG00000050534 AllianceGenome:MGI:96284
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5-Ht5b
Summary: Enables G protein-coupled serotonin receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-inhibiting serotonin receptor signaling pathway; and chemical synaptic transmission. Predicted to be active in dendrite and plasma membrane. Is expressed in several structures, including adrenal gland; central nervous system; eye; incisor; and male reproductive gland or organ. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 3.1), genital fat pad adult (RPKM 0.7) and 4 other tissues See more
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Genomic context

Location:: 1 E2.3; 1 52.98 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (121437487..121458351, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (121509758..121529312, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Atf-7-deficient mice exhibit abnormal behaviours and increased 5-HT receptor 5B (Htr5b) mRNA levels in the dorsal raphe nuclei.
Title: Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

General gene information

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Markers

X69867 (e-PCR)
- UniSTS:178452

Htr5b (e-PCR), detects polymorphism
- UniSTS:143429

NoName (e-PCR)
- UniSTS:490723

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables Gi/o-coupled serotonin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 5B

Names: 5-HT-5B; protein-tyrosine-phosphatase (EC 3.1.3.48) Ly-5 precursor (B-cell variant); serotonin receptor 5B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010483.3 → NP_034613.2 5-hydroxytryptamine receptor 5B

See identical proteins and their annotated locations for NP_034613.2

Status: VALIDATED

Source sequence(s)

AC111011

Consensus CDS

CCDS15239.1

UniProtKB/Swiss-Prot

P31387, Q1RME2

UniProtKB/TrEMBL

G3X9C6

Related

ENSMUSP00000057212.8, ENSMUST00000055884.8

Conserved Domains (1) summary

pfam00001
Location:69 → 351

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

121437487..121458351 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017317180.2 → XP_017172669.1 5-hydroxytryptamine receptor 5B isoform X1

Conserved Domains (2) summary

cd14964
Location:87 → 113

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:65 → 241

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily