U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ct55 cancer/testis antigen 55 [ Mus musculus (house mouse) ]

    Gene ID: 75013, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ct55provided by MGI
    Official Full Name
    cancer/testis antigen 55provided by MGI
    Primary source
    MGI:MGI:1922263
    See related
    Ensembl:ENSMUSG00000055555 AllianceGenome:MGI:1922263
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930502E18Rik
    Summary
    Involved in spermatogenesis. Located in acrosomal vesicle and sperm flagellum. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 7. Orthologous to human CT55 (cancer/testis antigen 55). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in placenta adult (RPKM 2.0), testis adult (RPKM 1.6) and 3 other tissues See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ct55 in Genome Data Viewer
    Location:
    X A5; X 29.99 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (52726622..52740532)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (53724655..53738565)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene 53064 Neighboring gene expressed sequence AW822252 Neighboring gene RIKEN cDNA 1700013H16 gene Neighboring gene predicted pseudogene 6025

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cancer testis antigen 55 deficiency attenuates colitis-associated colorectal cancer by inhibiting NF-κB signaling. Zhao H, et al. Cell Death Dis, 2019 Apr 3. PMID 30944312, Free PMC Article
    2. Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice. Zhang G, et al. Cell Death Differ, 2023 Feb. PMID 36481789, Free PMC Article
    3. Novel BRCA2-interacting protein BJ-HCC-20A inhibits the induction of apoptosis in response to DNA damage. Tomiyoshi G, et al. Cancer Sci, 2008 Apr. PMID 18307534, Free PMC Article
    4. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cancer/testis antigen 55

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029142.1 → NP_083418.1  cancer/testis antigen 55

      See identical proteins and their annotated locations for NP_083418.1

      Status: PROVISIONAL

      Source sequence(s)
      BC115664
      Consensus CDS
      CCDS30136.1
      UniProtKB/Swiss-Prot
      Q14BQ3, Q9D585
      Related
      ENSMUSP00000064619.2, ENSMUST00000069209.2
      Conserved Domains (1) summary
      pfam14444
      Location:176 → 228
      S1-like; S1-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      52726622..52740532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535359.2 → XP_006535422.1  cancer/testis antigen 55 isoform X1

      UniProtKB/TrEMBL
      A0A9L6KDX3
      Conserved Domains (1) summary
      pfam14444
      Location:111 → 163
      S1-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14BQ3.1 GenPept UniProtKB/Swiss-Prot:Q14BQ3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools