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    Hoxd13 homeobox D13 [ Mus musculus (house mouse) ]

    Gene ID: 15433, updated on 4-Jan-2025

    Summary

    Official Symbol
    Hoxd13provided by MGI
    Official Full Name
    homeobox D13provided by MGI
    Primary source
    MGI:MGI:96205
    See related
    Ensembl:ENSMUSG00000001819 AllianceGenome:MGI:96205
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    spdh; Hox-4.8
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within several processes, including embryonic digit morphogenesis; morphogenesis of an epithelium; and regulation of branching involved in prostate gland morphogenesis. Located in nucleus. Is expressed in several structures, including genitourinary system; hindgut; limb; limb bud; and tail. Used to study synpolydactyly. Human ortholog(s) of this gene implicated in brachydactyly-syndactyly syndrome; clubfoot; cryptorchidism; and dysostosis (multiple). Orthologous to human HOXD13 (homeobox D13). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in limb E14.5 (RPKM 44.7), colon adult (RPKM 15.1) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Hoxd13 in Genome Data Viewer
    Location:
    2 C3; 2 44.13 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (74498569..74501947)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (74668225..74671603)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene even-skipped homeobox 2 Neighboring gene predicted gene, 31790 Neighboring gene homeobox D12 Neighboring gene homeobox D11 Neighboring gene homeobox D10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior/posterior pattern specification PubMed 
    acts_upstream_of_or_within branch elongation of an epithelium PubMed 
    acts_upstream_of_or_within embryonic digit morphogenesis PubMed 
    involved_in embryonic hindgut morphogenesis  
    involved_in embryonic hindgut morphogenesis  
    acts_upstream_of_or_within embryonic limb morphogenesis PubMed 
    acts_upstream_of_or_within gland morphogenesis PubMed 
    acts_upstream_of_or_within limb morphogenesis PubMed 
    acts_upstream_of_or_within limb morphogenesis PubMed 
    acts_upstream_of_or_within male genitalia development PubMed 
    acts_upstream_of_or_within morphogenesis of an epithelial fold PubMed 
    acts_upstream_of_or_within pattern specification process PubMed 
    acts_upstream_of_or_within pattern specification process PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis PubMed 
    acts_upstream_of_or_within regulation of branching involved in prostate gland morphogenesis PubMed 
    acts_upstream_of_or_within regulation of cell population proliferation PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    involved_in response to testosterone  
    acts_upstream_of_or_within skeletal system development PubMed 
    acts_upstream_of transcription by RNA polymerase II PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    homeobox protein Hox-D13
    Names
    homeo box D13
    homeobox protein Hox-4.8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008275.4NP_032301.2  homeobox protein Hox-D13

      See identical proteins and their annotated locations for NP_032301.2

      Status: VALIDATED

      Source sequence(s)
      AL928644
      Consensus CDS
      CCDS16139.1
      UniProtKB/Swiss-Prot
      A2ASM5, P70217, Q2VPB0, Q2VPB1, Q64177
      Related
      ENSMUSP00000001872.5, ENSMUST00000001872.5
      Conserved Domains (2) summary
      pfam00046
      Location:275329
      Homeobox; Homeobox domain
      pfam12284
      Location:121168
      HoxA13_N; Hox protein A13 N terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      74498569..74501947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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