Sirpa signal-regulatory protein alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sirpaprovided by MGI
Official Full Name: signal-regulatory protein alphaprovided by MGI
Primary source: MGI:MGI:108563
See related: Ensembl:ENSMUSG00000037902 AllianceGenome:MGI:108563
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bit; P84; SIRP; SHP-1; CD172a; Ptpns1; SHPS-1; Idd13.2
Summary: Enables protein phosphatase binding activity; protein phosphatase inhibitor activity; and protein phosphorylated amino acid binding activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of nitric oxide biosynthetic process; and negative regulation of signal transduction. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; phagocytosis; and positive regulation of phagocytosis. Located in plasma membrane. Is expressed in several structures, including adrenal gland; cartilage; central nervous system; genitourinary system; and retina. Orthologous to human SIRPA (signal regulatory protein alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in cortex adult (RPKM 59.8), frontal lobe adult (RPKM 57.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F1; 2 63.19 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (129432962..129474148)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (129591042..129632228)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Podocyte SIRPalpha reduction aggravates lupus nephritis via promoting T cell inflammatory responses.
Title: Podocyte SIRPα reduction aggravates lupus nephritis via promoting T cell inflammatory responses.
Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPalpha.
Title: Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPα.
SIRP-alpha-IL-6 axis induces immunosuppressive macrophages in non-small-cell lung cancer.
Title: SIRP-alpha-IL-6 axis induces immunosuppressive macrophages in non-small-cell lung cancer.
Blocking the CD47-SIRPalpha interaction reverses the disease phenotype in a polycythemia vera mouse model.
Title: Blocking the CD47-SIRPα interaction reverses the disease phenotype in a polycythemia vera mouse model.
Neuronal signal-regulatory protein alpha drives microglial phagocytosis by limiting microglial interaction with CD47 in the retina.
Title: Neuronal signal-regulatory protein alpha drives microglial phagocytosis by limiting microglial interaction with CD47 in the retina.
SIRPalpha maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis.
Title: SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis.
SIRPalpha Mediates IGF1 Receptor in Cardiomyopathy Induced by Chronic Kidney Disease.
Title: SIRPα Mediates IGF1 Receptor in Cardiomyopathy Induced by Chronic Kidney Disease.
Endothelial SIRPalpha signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells.
Title: Endothelial SIRPα signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells.
SIRPalpha - CD47 axis regulates dendritic cell-T cell interactions and TCR activation during T cell priming in spleen.
Title: SIRPα - CD47 axis regulates dendritic cell-T cell interactions and TCR activation during T cell priming in spleen.
Augmentation of CD47/SIRPalpha signaling protects cones in genetic models of retinal degeneration.
Title: Augmentation of CD47/SIRPα signaling protects cones in genetic models of retinal degeneration.

Submit: New GeneRIF Correction See all GeneRIFs (131)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (11) 1 citation
QTL (1)
Targeted (10) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI835480 (e-PCR)
- UniSTS:178709

D87968 (e-PCR)
- UniSTS:159028

Sirpa (e-PCR), detects polymorphism
- UniSTS:141178

RH125140 (e-PCR)
- UniSTS:161962

Ptpns1 (e-PCR), detects polymorphism
- UniSTS:144303

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase regulator activity	ISO Inferred from Sequence Orthology more info
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables cell-cell adhesion mediator activity	ISO Inferred from Sequence Orthology more info
enables protein antigen binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding involved in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein phosphorylated amino acid binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell motility	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-12	ISO Inferred from Sequence Orthology more info
involved_in cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in granulocyte migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monocyte extravasation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of chemokine (C-C motif) ligand 5 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytokine production involved in inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cytokine production involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interferon-beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lipopolysaccharide-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of macrophage inflammatory protein 1 alpha production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phagocytosis, engulfment	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phagocytosis, recognition	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of phagocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of type II interferon production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: tyrosine-protein phosphatase non-receptor type substrate 1

Names: CD172 antigen-like family member A; SHP substrate 1; brain Ig-like molecule with tyrosine-based activation motifs; brain immunological-like with tyrosine-based motifs; inhibitory receptor SHPS-1; mSIRP-alpha1; myD-1 antigen; protein tyrosine phosphatase, non-receptor type substrate 1; signal-regulatory protein alpha-1; sirp-alpha-1

NP_001171118.1

EC 3.1.3.48

NP_001277948.1

EC 3.1.3.48

NP_001277949.1

EC 3.1.3.48

NP_001277950.1

EC 3.1.3.48

NP_001277951.1

EC 3.1.3.48

NP_001342087.1

EC 3.1.3.48

NP_001342089.1

EC 3.1.3.48

NP_001407695.1

EC 3.1.3.48

NP_001407696.1

EC 3.1.3.48

NP_001407697.1

EC 3.1.3.48

NP_001407698.1

EC 3.1.3.48

NP_001407699.1

EC 3.1.3.48

NP_001407700.1

EC 3.1.3.48

NP_001407701.1

EC 3.1.3.48

NP_031573.2

EC 3.1.3.48

XP_017172053.1

EC 3.1.3.48

XP_017172057.1

EC 3.1.3.48

XP_017172058.1

EC 3.1.3.48

XP_030104595.1

EC 3.1.3.48

XP_030104598.1

EC 3.1.3.48

XP_036015585.1

EC 3.1.3.48

XP_036015587.1

EC 3.1.3.48

XP_036015588.1

EC 3.1.3.48

XP_036015589.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177647.3 → NP_001171118.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_001171118.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two alternate in-frame exons in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 4. The encoded isoform (2) is shorter than isoform 3.

Source sequence(s)

AL808126

Consensus CDS

CCDS50708.1

UniProtKB/Swiss-Prot

P97797

UniProtKB/TrEMBL

A0A0R4J1Z7

Related

ENSMUSP00000125004.2, ENSMUST00000160276.2

Conserved Domains (1) summary

cl11960
Location:35 → 146

Ig; Immunoglobulin domain
NM_001291019.2 → NP_001277948.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 3 precursor

See identical proteins and their annotated locations for NP_001277948.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (3). Both variants 4 and 5 encode isoform 3.

Source sequence(s)

AL808126

Consensus CDS

CCDS71142.1

UniProtKB/Swiss-Prot

A0A0R4J1Z7, E0CYM8, E9QPT7, O08907, O35924, O88555, O88556, P97796, P97797, Q8R559, Q9QX57, Q9WTN4

UniProtKB/TrEMBL

Q2M4I8

Related

ENSMUSP00000049022.8, ENSMUST00000049262.14

Conserved Domains (4) summary

cd00096
Location:35 → 38

Ig; Ig strand A [structural motif]

cd05772
Location:148 → 250

IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains

cd16085
Location:253 → 348

IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains

cl11960
Location:35 → 146

Ig; Immunoglobulin domain
NM_001291020.2 → NP_001277949.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 3 precursor

See identical proteins and their annotated locations for NP_001277949.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. Both variants 4 and 5 encode isoform 3.

Source sequence(s)

AL808126

Consensus CDS

CCDS71142.1

UniProtKB/Swiss-Prot

A0A0R4J1Z7, E0CYM8, E9QPT7, O08907, O35924, O88555, O88556, P97796, P97797, Q8R559, Q9QX57, Q9WTN4

UniProtKB/TrEMBL

Q2M4I8

Related

ENSMUSP00000124048.2, ENSMUST00000161620.8

Conserved Domains (4) summary

cd00096
Location:35 → 38

Ig; Ig strand A [structural motif]

cd05772
Location:148 → 250

IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains

cd16085
Location:253 → 348

IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains

cl11960
Location:35 → 146

Ig; Immunoglobulin domain
NM_001291021.2 → NP_001277950.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 4 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (6) lacks two alternate in-frame exons in the central coding region, compared to variant 4, resulting in an isoform (4) that is shorter than isoform 3. Variants 6 and 10 both encode the same isoform (4).

Source sequence(s)

AL808126

Consensus CDS

CCDS71143.1

UniProtKB/TrEMBL

E9QPT7

Related

ENSMUSP00000096713.4, ENSMUST00000099113.10

Conserved Domains (1) summary

cl11960
Location:35 → 146

Ig; Immunoglobulin domain
NM_001291022.2 → NP_001277951.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (7) lacks an alternate in-frame exon in the 5' coding region and two in-frame exons in the central coding region, and also uses an alternate in-frame splice site in the 3' coding region, compared to variant 4. The encoded isoform (5) is shorter than isoform 3.

Source sequence(s)

AL808126

Consensus CDS

CCDS79845.1

UniProtKB/TrEMBL

E0CX65

Related

ENSMUSP00000124888.2, ENSMUST00000163034.8
NM_001355158.2 → NP_001342087.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (8) encodes isoform 1. Variants 1, 8, 11, and 12 all encode the same isoform (1).

Source sequence(s)

AL808126

Consensus CDS

CCDS16729.1

UniProtKB/TrEMBL

Q2M4I8, Q6P6I8

Related

ENSMUSP00000137611.2, ENSMUST00000179001.8

Conserved Domains (3) summary

cd05772
Location:148 → 251

IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2

cd16085
Location:253 → 356

IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3

cl11960
Location:35 → 146

Ig; Immunoglobulin domain
NM_001355160.1 → NP_001342089.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 6

Status: VALIDATED

Source sequence(s)

AL808126

UniProtKB/TrEMBL

Q2M4I8

Conserved Domains (3) summary

cd05772
Location:136 → 239

IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2

cd16085
Location:241 → 344

IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3

cl11960
Location:23 → 134

Ig; Immunoglobulin domain
NM_001420766.1 → NP_001407695.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AL808126

UniProtKB/Swiss-Prot

A0A0R4J1Z7, E0CYM8, E9QPT7, O08907, O35924, O88555, O88556, P97796, P97797, Q8R559, Q9QX57, Q9WTN4

UniProtKB/TrEMBL

Q2M4I8
NM_001420767.1 → NP_001407696.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL808126

UniProtKB/TrEMBL

Q2M4I8, Q6P6I8

Related

ENSMUSP00000099492.2, ENSMUST00000103203.8
NM_001420768.1 → NP_001407697.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL808126

UniProtKB/TrEMBL

Q2M4I8, Q6P6I8
NM_001420769.1 → NP_001407698.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 7 precursor

Status: VALIDATED

Source sequence(s)

AL808126
NM_001420770.1 → NP_001407699.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 8

Status: VALIDATED

Source sequence(s)

AL808126
NM_001420771.1 → NP_001407700.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 9

Status: VALIDATED

Source sequence(s)

AL808126
NM_001420772.1 → NP_001407701.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 10

Status: VALIDATED

Source sequence(s)

AL808126
NM_007547.5 → NP_031573.2 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_031573.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region, compared to variant 4, resulting in an isoform (1) that is shorter than isoform 3. Variants 1, 8, 11, and 12 all encode the same isoform (1).

Source sequence(s)

AL808126

Consensus CDS

CCDS16729.1

UniProtKB/TrEMBL

Q2M4I8, Q6P6I8

Related

ENSMUSP00000099491.4, ENSMUST00000103202.10

Conserved Domains (3) summary

cd05772
Location:148 → 251

IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2

cd16085
Location:253 → 356

IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3

cl11960
Location:35 → 146

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

129432962..129474148

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017316564.2 → XP_017172053.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

UniProtKB/TrEMBL

Q2M4I8

Conserved Domains (4) summary

cd00096
Location:28 → 31

Ig; Ig strand A [structural motif]

cd05772
Location:141 → 243

IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains

cd16085
Location:246 → 341

IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains

cl11960
Location:28 → 139

Ig; Immunoglobulin domain
XM_036159695.1 → XP_036015588.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2

UniProtKB/TrEMBL

Q2M4I8

Conserved Domains (4) summary

cd00096
Location:28 → 31

Ig; Ig strand A [structural motif]

cd05772
Location:141 → 243

IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains

cd16085
Location:246 → 341

IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains

cl11960
Location:28 → 139

Ig; Immunoglobulin domain
XM_017316568.2 → XP_017172057.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform X5

UniProtKB/TrEMBL

E9QPT7

Conserved Domains (1) summary

cl11960
Location:35 → 146

Ig; Immunoglobulin domain
XM_017316569.2 → XP_017172058.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform X6

UniProtKB/Swiss-Prot

P97797

UniProtKB/TrEMBL

A0A0R4J1Z7

Conserved Domains (1) summary

cl11960
Location:35 → 146

Ig; Immunoglobulin domain
XM_036159694.1 → XP_036015587.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

UniProtKB/TrEMBL

Q2M4I8

Conserved Domains (4) summary

cd00096
Location:28 → 31

Ig; Ig strand A [structural motif]

cd05772
Location:141 → 243

IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains

cd16085
Location:246 → 341

IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains

cl11960
Location:28 → 139

Ig; Immunoglobulin domain
XM_036159692.1 → XP_036015585.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform X3

UniProtKB/Swiss-Prot

A0A0R4J1Z7, E0CYM8, E9QPT7, O08907, O35924, O88555, O88556, P97796, P97797, Q8R559, Q9QX57, Q9WTN4

UniProtKB/TrEMBL

Q2M4I8

Conserved Domains (4) summary

cd00096
Location:35 → 38

Ig; Ig strand A [structural motif]

cd05772
Location:148 → 250

IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains

cd16085
Location:253 → 348

IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains

cl11960
Location:35 → 146

Ig; Immunoglobulin domain
XM_030248735.2 → XP_030104595.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

UniProtKB/TrEMBL

Q2M4I8

Conserved Domains (4) summary

cd00096
Location:28 → 31

Ig; Ig strand A [structural motif]

cd05772
Location:141 → 243

IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains

cd16085
Location:246 → 341

IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains

cl11960
Location:28 → 139

Ig; Immunoglobulin domain
XM_030248738.2 → XP_030104598.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2

UniProtKB/TrEMBL

Q2M4I8

Conserved Domains (4) summary

cd00096
Location:28 → 31

Ig; Ig strand A [structural motif]

cd05772
Location:141 → 243

IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains

cd16085
Location:246 → 341

IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains

cl11960
Location:28 → 139

Ig; Immunoglobulin domain
XM_036159696.1 → XP_036015589.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2

UniProtKB/TrEMBL

Q2M4I8

Conserved Domains (4) summary

cd00096
Location:28 → 31

Ig; Ig strand A [structural motif]

cd05772
Location:141 → 243

IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains

cd16085
Location:246 → 341

IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains

cl11960
Location:28 → 139

Ig; Immunoglobulin domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001177646.1: Suppressed sequence

Description

NM_001177646.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.