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    Wdr25 WD repeat domain 25 [ Mus musculus (house mouse) ]

    Gene ID: 212198, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wdr25provided by MGI
    Official Full Name
    WD repeat domain 25provided by MGI
    Primary source
    MGI:MGI:3045255
    See related
    Ensembl:ENSMUSG00000040877 AllianceGenome:MGI:3045255
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B930090D16Rik
    Summary
    Orthologous to human WDR25 (WD repeat domain 25). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 3.5), testis adult (RPKM 1.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Wdr25 in Genome Data Viewer
    Location:
    12 F1; 12 59.7 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (108860155..108994380)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (108894152..109028454)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25, member 47 Neighboring gene predicted gene, 22079 Neighboring gene tryptophanyl-tRNA synthetase1 Neighboring gene STARR-positive B cell enhancer ABC_E5353 Neighboring gene STARR-seq mESC enhancer starr_33252 Neighboring gene STARR-seq mESC enhancer starr_33253 Neighboring gene STARR-seq mESC enhancer starr_33254 Neighboring gene peptidyl prolyl isomerase H pseudogene Neighboring gene STARR-seq mESC enhancer starr_33255 Neighboring gene brain-enriched guanylate kinase-associated Neighboring gene predicted gene, 52002 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:110295982-110296239 Neighboring gene STARR-positive B cell enhancer mm9_chr12:110312387-110312688 Neighboring gene STARR-positive B cell enhancer mm9_chr12:110313106-110313407 Neighboring gene macrophage migration inhibitory factor, pseudogene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177602.3 → NP_808270.2  WD repeat-containing protein 25

      See identical proteins and their annotated locations for NP_808270.2

      Status: VALIDATED

      Source sequence(s)
      AC122811, AC140111
      Consensus CDS
      CCDS49172.1
      UniProtKB/Swiss-Prot
      E9Q349, Q8C4T7
      Related
      ENSMUSP00000129855.2, ENSMUST00000167816.8
      Conserved Domains (2) summary
      cd00200
      Location:230 → 534
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:242 → 281
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      108860155..108994380
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515661.4 → XP_006515724.1  WD repeat-containing protein 25 isoform X2

      Conserved Domains (2) summary
      sd00039
      Location:240 → 280
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:230 → 358
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_011244056.4 → XP_011242358.1  WD repeat-containing protein 25 isoform X4

      Conserved Domains (2) summary
      sd00039
      Location:240 → 280
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:230 → 360
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_006515660.5 → XP_006515723.1  WD repeat-containing protein 25 isoform X1

      See identical proteins and their annotated locations for XP_006515723.1

      UniProtKB/Swiss-Prot
      E9Q349, Q8C4T7
      Conserved Domains (2) summary
      cd00200
      Location:230 → 534
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:242 → 281
      7WD40; WD40 repeat [structural motif]

    4. XM_011244054.4 → XP_011242356.1  WD repeat-containing protein 25 isoform X1

      See identical proteins and their annotated locations for XP_011242356.1

      UniProtKB/Swiss-Prot
      E9Q349, Q8C4T7
      Conserved Domains (2) summary
      cd00200
      Location:230 → 534
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:242 → 281
      7WD40; WD40 repeat [structural motif]

    5. XM_006515657.4 → XP_006515720.1  WD repeat-containing protein 25 isoform X1

      See identical proteins and their annotated locations for XP_006515720.1

      UniProtKB/Swiss-Prot
      E9Q349, Q8C4T7
      Conserved Domains (2) summary
      cd00200
      Location:230 → 534
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:242 → 281
      7WD40; WD40 repeat [structural motif]

    6. XM_006515662.4 → XP_006515725.1  WD repeat-containing protein 25 isoform X3

      Conserved Domains (2) summary
      sd00039
      Location:241 → 282
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:228 → 441
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    7. XM_011244057.4 → XP_011242359.1  WD repeat-containing protein 25 isoform X5

      Conserved Domains (2) summary
      sd00039
      Location:240 → 280
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:230 → 349
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    8. XM_011244055.3 → XP_011242357.1  WD repeat-containing protein 25 isoform X1

      See identical proteins and their annotated locations for XP_011242357.1

      UniProtKB/Swiss-Prot
      E9Q349, Q8C4T7
      Related
      ENSMUSP00000035553.8, ENSMUST00000047115.9
      Conserved Domains (2) summary
      cd00200
      Location:230 → 534
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:242 → 281
      7WD40; WD40 repeat [structural motif]

    9. XM_006515658.4 → XP_006515721.1  WD repeat-containing protein 25 isoform X1

      See identical proteins and their annotated locations for XP_006515721.1

      UniProtKB/Swiss-Prot
      E9Q349, Q8C4T7
      Conserved Domains (2) summary
      cd00200
      Location:230 → 534
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:242 → 281
      7WD40; WD40 repeat [structural motif]

    RNA

    1. XR_003950025.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q349.1 GenPept UniProtKB/Swiss-Prot:E9Q349

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