Kcnk10 potassium two pore domain channel subfamily K member 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnk10provided by RGD
Official Full Name: potassium two pore domain channel subfamily K member 10provided by RGD
Primary source: RGD:619732
See related: EnsemblRapid:ENSRNOG00000003813 AllianceGenome:RGD:619732
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TREK2
Summary: Enables potassium channel activity. Involved in memory. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Biomarker of brain ischemia. Orthologous to human KCNK10 (potassium two pore domain channel subfamily K member 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 36.4), Testes (RPKM 23.5) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (123419778..123555820, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (117690052..117826120, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (122417079..122549532, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glial-derived neurotrophic factor regulates the expression of TREK2 in rat primary sensory neurons leading to attenuation of axotomy-induced neuropathic pain.
Title: Glial-derived neurotrophic factor regulates the expression of TREK2 in rat primary sensory neurons leading to attenuation of axotomy-induced neuropathic pain.
Effects of GABAB receptor activation on excitability of IB4-positive maxillary trigeminal ganglion neurons: Possible involvement of TREK2 activation.
Title: Effects of GABA(B) receptor activation on excitability of IB4-positive maxillary trigeminal ganglion neurons: Possible involvement of TREK2 activation.
strong immunoreactivity of TRAAK, TREK-1 and TREK-2 channels was present mainly in small-sized dorsal root ganglion (DRG) neurons of rats.
Title: Characterization of temperature-sensitive leak K(+) currents and expression of TRAAK, TREK-1, and TREK2 channels in dorsal root ganglion neurons of rats.
Data do not suggest a relevant impact of miRNA expression patterns on the pharmacoresponsiveness of temporal lobe epilepsy; but confirmed the regulation of the previously described miRNA-187-3p and demonstrated that its regulation can exert an impact on the expression of the two-pore domain potassium channel protein KCNK10/TREK-2.
Title: miRNA-187-3p-Mediated Regulation of the KCNK10/TREK-2 Potassium Channel in a Rat Epilepsy Model.
Up-regulation of TREK-2 potassium channels in cultured astrocytes requires de novo protein synthesis.TREK-2 channels are up-regulated in the astrocytic membrane during ischemia.
Title: Up-regulation of TREK-2 potassium channels in cultured astrocytes requires de novo protein synthesis: relevance to localization of TREK-2 channels in astrocytes after transient cerebral ischemia.
KCNK10 contributes to the regulation of MCE through the control of C/EBPbeta and C/EBPdelta expression and insulin signaling.
Title: KCNK10, a tandem pore domain potassium channel, is a regulator of mitotic clonal expansion during the early stage of adipocyte differentiation.
We conclude that TREK2 hyperpolarizes IB4 binding C-nociceptors and limits pathological spontaneous pain.
Title: TREK2 expressed selectively in IB4-binding C-fiber nociceptors hyperpolarizes their membrane potentials and limits spontaneous pain.
In the dorsal horn of the developing rat, KCNK10 mRNA was decreased in mature compared with developing rats.
Title: Transcriptional expression of voltage-gated Na⁺ and voltage-independent K⁺ channels in the developing rat superficial dorsal horn.
These results suggest that baicalein- and wogonin-induced TREK-2 activation help set the resting membrane potential of cells exposed to pathological conditions and thus may give beneficial effects in neuroprotection.
Title: Baicalein and wogonin are activators of rat TREK-2 two-pore domain K+ channel.
GABA(B) receptor-mediated inhibition in the EC was mediated via activating TREK-2, a type of two-pore domain K(+) channels, and required the functions of inhibitory G proteins and protein kinase A pathway.
Title: GABA(B) receptor activation inhibits neuronal excitability and spatial learning in the entorhinal cortex by activating TREK-2 K+ channels.

Submit: New GeneRIF Correction See all GeneRIFs (19)

General gene information

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Markers

Kcnk10 (e-PCR), detects polymorphism
- UniSTS:547591

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mechanosensitive potassium channel activity	ISO Inferred from Sequence Orthology more info
enables mechanosensitive potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables outward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables outward rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium ion leak channel activity	ISO Inferred from Sequence Orthology more info
enables potassium ion leak channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to arachidonate	ISO Inferred from Sequence Orthology more info
involved_in cellular response to arachidonate	ISS Inferred from Sequence or Structural Similarity more info
involved_in memory	IEP Inferred from Expression Pattern more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: potassium channel subfamily K member 10

Names: TREK-2 K(+) channel subunit; outward rectifying potassium channel protein TREK-2; potassium channel TREK-2; potassium channel, subfamily K, member 10; potassium channel, two pore domain subfamily K, member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023096.3 → NP_075584.1 potassium channel subfamily K member 10

See identical proteins and their annotated locations for NP_075584.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q548D8, Q9JIS4

UniProtKB/TrEMBL

A6JEE3

Related

ENSRNOP00000005175.3, ENSRNOT00000005175.6

Conserved Domains (1) summary

pfam07885
Location:148 → 206

Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

123419778..123555820 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017594351.3 → XP_017449840.1 potassium channel subfamily K member 10 isoform X1

UniProtKB/TrEMBL

A0A8I6AXI0, A6JEE2

Related

ENSRNOP00000107366.1, ENSRNOT00000141601.1

Conserved Domains (1) summary

pfam07885
Location:145 → 203

Ion_trans_2; Ion channel
XM_008764847.4 → XP_008763069.1 potassium channel subfamily K member 10 isoform X2

UniProtKB/TrEMBL

A0A8I6AHS2

Related

ENSRNOP00000092512.1, ENSRNOT00000111719.2

Conserved Domains (1) summary

pfam07885
Location:131 → 189

Ion_trans_2; Ion channel
XM_039112918.2 → XP_038968846.1 potassium channel subfamily K member 10 isoform X4

Conserved Domains (1) summary

pfam07885
Location:148 → 206

Ion_trans_2; Ion channel
XM_063262460.1 → XP_063118530.1 potassium channel subfamily K member 10 isoform X3