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    Wwc2 WW, C2 and coiled-coil domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 52357, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wwc2provided by MGI
    Official Full Name
    WW, C2 and coiled-coil domain containing 2provided by MGI
    Primary source
    MGI:MGI:1261872
    See related
    Ensembl:ENSMUSG00000031563 AllianceGenome:MGI:1261872
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D8Ertd594e; 5330431C14Rik
    Summary
    Predicted to enable kinase binding activity and signaling adaptor activity. Predicted to be involved in several processes, including hippo signaling; negative regulation of hippo signaling; and negative regulation of organ growth. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in telencephalon. Orthologous to human WWC2 (WW and C2 domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 18.6), testis adult (RPKM 13.9) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Wwc2 in Genome Data Viewer
    Location:
    8 B1.1; 8 26.91 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (48279117..48443579, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (47826082..47990544, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene claudin 24 Neighboring gene claudin 22 Neighboring gene predicted gene, 39173 Neighboring gene STARR-seq mESC enhancer starr_21422 Neighboring gene STARR-seq mESC enhancer starr_21423 Neighboring gene predicted gene, 31984 Neighboring gene predicted gene, 32052 Neighboring gene STARR-seq mESC enhancer starr_21426 Neighboring gene STARR-seq mESC enhancer starr_21427 Neighboring gene STARR-seq mESC enhancer starr_21428 Neighboring gene dCMP deaminase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in hippo signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hippo signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of hippo signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of hippo signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of organ growth IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of organ growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of organ growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein WWC2
    Names
    WW domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133791.5NP_598552.2  protein WWC2

      See identical proteins and their annotated locations for NP_598552.2

      Status: VALIDATED

      Source sequence(s)
      AC110509, AC161202
      Consensus CDS
      CCDS22301.1
      UniProtKB/Swiss-Prot
      Q3UGG4, Q3UH10, Q6NXJ0, Q7TMY1, Q8CE61, Q9JJ63
      Related
      ENSMUSP00000056121.8, ENSMUST00000057561.9
      Conserved Domains (3) summary
      cd08680
      Location:699822
      C2_Kibra; C2 domain found in Human protein Kibra
      pfam00397
      Location:1241
      WW; WW domain
      cl01720
      Location:10881146
      Phage_Nu1; Phage DNA packaging protein Nu1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      48279117..48443579 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154163.1XP_036010056.1  protein WWC2 isoform X1

      Conserved Domains (4) summary
      cd08680
      Location:676799
      C2_Kibra; C2 domain found in Human protein Kibra
      COG1196
      Location:75392
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd06503
      Location:10511138
      ATP-synt_Fo_b; F-type ATP synthase, membrane subunit b
      pfam00397
      Location:3665
      WW; WW domain