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    CPB1 carboxypeptidase B1 [ Homo sapiens (human) ]

    Gene ID: 1360, updated on 9-Dec-2024

    Summary

    Official Symbol
    CPB1provided by HGNC
    Official Full Name
    carboxypeptidase B1provided by HGNC
    Primary source
    HGNC:HGNC:2299
    See related
    Ensembl:ENSG00000153002 MIM:114852; AllianceGenome:HGNC:2299
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPB; PASP; PCPB
    Summary
    Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2 forms differ from each other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward pancreas (RPKM 27892.6) See more
    Orthologs
    NEW
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    Genomic context

    See CPB1 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (148827811..148860187)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (151578867..151610937)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (148545598..148577974)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene angiotensin II receptor type 1 Neighboring gene NANOG hESC enhancer GRCh37_chr3:148472851-148473352 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:148498709-148498859 Neighboring gene high mobility group box 1 pseudogene 30 Neighboring gene carboxypeptidase A3 Neighboring gene uncharacterized LOC107986045

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • DKFZp779K1333

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carboxypeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    carboxypeptidase B
    Names
    carboxypeptidase B1 (tissue)
    pancreas-specific protein
    pancreatic carboxypeptidase B
    procarboxypeptidase B
    protaminase
    tissue carboxypeptidase B
    NP_001862.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001871.3NP_001862.2  carboxypeptidase B preproprotein

      See identical proteins and their annotated locations for NP_001862.2

      Status: REVIEWED

      Source sequence(s)
      BC015338, BI770145
      Consensus CDS
      CCDS33874.1
      UniProtKB/Swiss-Prot
      O60834, P15086, Q53XJ0, Q96BQ8
      Related
      ENSP00000282957.4, ENST00000282957.9
      Conserved Domains (2) summary
      cd03871
      Location:114413
      M14_CPB; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase B subgroup
      pfam02244
      Location:29103
      Propep_M14; Carboxypeptidase activation peptide

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      148827811..148860187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      151578867..151610937
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)