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    AMY2B amylase alpha 2B [ Homo sapiens (human) ]

    Gene ID: 280, updated on 9-Dec-2024

    Summary

    Official Symbol
    AMY2Bprovided by HGNC
    Official Full Name
    amylase alpha 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:478
    See related
    Ensembl:ENSG00000240038 MIM:104660; AllianceGenome:HGNC:478
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HXA; AMY2; AMY3
    Summary
    Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas. [provided by RefSeq, Jun 2013]
    Expression
    Biased expression in pancreas (RPKM 6104.1) and salivary gland (RPKM 774.6) See more
    Orthologs
    NEW
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    Genomic context

    See AMY2B in Genome Data Viewer
    Location:
    1p21.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (103554644..103579534)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (103403587..103428477)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (104097266..104122156)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904593 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:103698107-103698264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1412 Neighboring gene RNPC3 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1128 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1413 Neighboring gene RN7SK pseudogene 285 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:104100112-104100330 Neighboring gene RNA binding region (RNP1, RRM) containing 3 Neighboring gene actin gamma 1 pseudogene 4 Neighboring gene amylase alpha 2A Neighboring gene amylase alpha 1A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: RNPC3

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables alpha-amylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables alpha-amylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    alpha-amylase 2B
    Names
    1,4-alpha-D-glucan glucanohydrolase 2B
    amylase alpha 2B (pancreatic)
    carcinoid alpha-amylase
    glycogenase
    NP_001373038.1
    NP_001374366.1
    NP_066188.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001386109.1NP_001373038.1  alpha-amylase 2B precursor

      Status: REVIEWED

      Source sequence(s)
      AC105272
      Consensus CDS
      CCDS782.1
      UniProtKB/Swiss-Prot
      B3KTI1, B3KXB7, D3DT76, P19961, Q9UBH3
      UniProtKB/TrEMBL
      Q53F26
      Conserved Domains (3) summary
      cd11317
      Location:25416
      AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
      smart00632
      Location:422510
      Aamy_C; Aamy_C domain
      PLN02447
      Location:85155
      PLN02447; 1,4-alpha-glucan-branching enzyme
    2. NM_001387437.1NP_001374366.1  alpha-amylase 2B precursor

      Status: REVIEWED

      Source sequence(s)
      AC105272
      Consensus CDS
      CCDS782.1
      UniProtKB/Swiss-Prot
      B3KTI1, B3KXB7, D3DT76, P19961, Q9UBH3
      UniProtKB/TrEMBL
      Q53F26
      Related
      ENSP00000507176.1, ENST00000684275.1
      Conserved Domains (3) summary
      cd11317
      Location:25416
      AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
      smart00632
      Location:422510
      Aamy_C; Aamy_C domain
      PLN02447
      Location:85155
      PLN02447; 1,4-alpha-glucan-branching enzyme
    3. NM_020978.4NP_066188.1  alpha-amylase 2B precursor

      See identical proteins and their annotated locations for NP_066188.1

      Status: REVIEWED

      Source sequence(s)
      AI436349, BC011179, DA157436, DB235608
      Consensus CDS
      CCDS782.1
      UniProtKB/Swiss-Prot
      B3KTI1, B3KXB7, D3DT76, P19961, Q9UBH3
      UniProtKB/TrEMBL
      Q53F26
      Related
      ENSP00000354610.4, ENST00000361355.8
      Conserved Domains (3) summary
      cd11317
      Location:25416
      AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
      smart00632
      Location:422510
      Aamy_C; Aamy_C domain
      PLN02447
      Location:85155
      PLN02447; 1,4-alpha-glucan-branching enzyme

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      103554644..103579534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      103403587..103428477
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)