Nup358 Nucleoporin 358kD [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Nup358provided by FlyBase
Official Full Name: Nucleoporin 358kDprovided by FlyBase
Primary source: FLYBASE:FBgn0039302
Locus tag: Dmel_CG11856
See related: AllianceGenome:FB:FBgn0039302
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11856; Dmel\CG11856; dmRanBP; nup358; NUP358; Q9VBU7_DROME; ranbp2; RanBP2
Summary: Predicted to enable SUMO transferase activity. Predicted to contribute to GTPase activator activity. Involved in several processes, including NLS-bearing protein import into nucleus; juvenile hormone mediated signaling pathway; and positive regulation of RNA export from nucleus. Located in annulate lamellae. Is expressed in adult head. Human ortholog(s) of this gene implicated in brain disease and inflammatory myofibroblastic tumor. Orthologous to several human genes including RANBP2 (RAN binding protein 2); RGPD1 (RANBP2 like and GRIP domain containing 1); and RGPD2 (RANBP2 like and GRIP domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 96C8-96C8; 3-87 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (25249348..25258672)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (21075070..21084394)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3beta signalling.
Title: Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling.
This study shows that nucleoporin 358 (Nup358) and Piwi interact with each other and that a germline knockdown (GLKD) of Nup358 with short hairpin RNA prevents Piwi entry into the nucleus.
Title: A critical role for nucleoporin 358 (Nup358) in transposon silencing and piRNA biogenesis in Drosophila.
facilitates JH-induced Met nuclear transport in a manner dependent on importin beta and Hsp83
Title: Nucleoporin Nup358 facilitates nuclear import of Methoprene-tolerant (Met) in an importin β- and Hsp83-dependent manner.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1700 (e-PCR)
- UniSTS:45497

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
contributes_to GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables SUMO transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular transport	IEA Inferred from Electronic Annotation more info
involved_in juvenile hormone mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear pore complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of RNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral cord development	HMP more info	PubMed

Component	Evidence Code	Pubs
located_in annulate lamellae	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nucleoporin 358kD

Names: CG11856-PA; CG11856-PB; Nup358-PA; Nup358-PB; nucleoporin 358

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

25249348..25258672

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001260373.2 → NP_001247302.1 nucleoporin 358kD, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247302.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0B4K7J2, D3DMF2, Q8SWV7, Q9VBU7

Conserved Domains (11) summary

COG0457
Location:14 → 128

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

cd13171
Location:1324 → 1442

RanBD1_RanBP2_insect-like; Ran-binding protein 2, Ran binding domain repeat 1

cd13172
Location:1620 → 1737

RanBD2_RanBP2_insect-like; Ran-binding protein 2, Ran binding domain repeat 2

cd13173
Location:2034 → 2148

RanBD3_RanBP2_insect-like; Ran-binding protein 2, Ran binding domain repeat 3

cd13174
Location:2571 → 2694

RanBD4_RanBP2_insect-like; Ran-binding protein 2, Ran binding domain repeat 4

sd00025
Location:1833 → 1861

zf-RanBP2; RanBP2-type Zn finger [structural motif]

sd00029
Location:1774 → 1793

zf-RanBP2; RanBP2-type Zn finger [structural motif]

sd00006
Location:58 → 90

TPR; TPR repeat [structural motif]

pfam00641
Location:1891 → 1917

zf-RanBP; Zn-finger in Ran binding protein and others

cl25599
Location:1806 → 1986

Nucleoporin_FG2; Nucleoporin FG repeated region

cl26464
Location:1030 → 1308

Atrophin-1; Atrophin-1 family
NM_143104.3 → NP_651361.2 nucleoporin 358kD, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651361.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9VBU7

Related

FBpp0084188

Conserved Domains (11) summary

smart00547
Location:1772 → 1796

ZnF_RBZ; Zinc finger domain

cd13171
Location:1324 → 1442

RanBD1_RanBP2_insect-like; Ran-binding protein 2, Ran binding domain repeat 1

cd13172
Location:1620 → 1737

RanBD2_RanBP2_insect-like; Ran-binding protein 2, Ran binding domain repeat 2

cd13173
Location:2034 → 2148

RanBD3_RanBP2_insect-like; Ran-binding protein 2, Ran binding domain repeat 3

cd13174
Location:2548 → 2671

RanBD4_RanBP2_insect-like; Ran-binding protein 2, Ran binding domain repeat 4

sd00029
Location:1774 → 1793

zf-RanBP2; RanBP2-type Zn finger [structural motif]

sd00006
Location:58 → 90

TPR; TPR repeat [structural motif]

pfam00641
Location:1891 → 1917

zf-RanBP; Zn-finger in Ran binding protein and others

pfam11235
Location:1081 → 1249

Med25_SD1; Mediator complex subunit 25 synapsin 1

pfam13432
Location:30 → 92

TPR_16; Tetratricopeptide repeat

pfam16768
Location:1817 → 1999

NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein