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    Parg Poly(ADP-ribose) glycohydrolase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31329, updated on 4-Jan-2025

    Summary

    Official Symbol
    Pargprovided by FlyBase
    Official Full Name
    Poly(ADP-ribose) glycohydrolaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023216
    Locus tag
    Dmel_CG2864
    See related
    AllianceGenome:FB:FBgn0023216
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2864; Dmel\CG2864; dParg; EG:114E2.1; HD10914; parg; PARG
    Summary
    Enables ADP-ribosylserine hydrolase activity and poly(ADP-ribose) glycohydrolase activity. Involved in several processes, including Cajal body organization; female germ-line stem cell population maintenance; and regulation of gene expression. Located in nucleoplasm. Is active in site of DNA damage. Used to study stress-induced childhood-onset neurodegeneration with variable ataxia and seizures. Orthologous to human BPHL (biphenyl hydrolase like) and PARG (poly(ADP-ribose) glycohydrolase). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See Parg in Genome Data Viewer
    Location:
    3E2-3E2; 1-4 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (3668837..3671502, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (3562870..3565535, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Dpr-interacting protein alpha Neighboring gene pickpocket 8 Neighboring gene uncharacterized protein Neighboring gene Allatostatin A receptor 1 Neighboring gene Insulin-like peptide 7 Neighboring gene long non-coding RNA:CR45102 Neighboring gene Mnt

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in nucleoplasm PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 
    is_active_in site of DNA damage PubMed 

    General protein information

    Preferred Names
    Poly(ADP-ribose) glycohydrolase
    Names
    CG2864-PB
    CG2864-PC
    Parg-PB
    Parg-PC
    Poly(ADP-ribose)glycohydrolase
    Poly(ADPribose) glyco-hydrolase
    NP_001245511.1
    NP_477321.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      3668837..3671502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057973.4 → NP_477321.2  Poly(ADP-ribose) glycohydrolase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477321.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9NEU9, O46043, Q960N8
      Conserved Domains (1) summary
      pfam05028
      Location:155 → 492
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
    2. NM_001258582.2 → NP_001245511.1  Poly(ADP-ribose) glycohydrolase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245511.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9NEU9, O46043, Q960N8
      Conserved Domains (1) summary
      pfam05028
      Location:155 → 492
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
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