LBR Lamin B receptor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: LBRprovided by FlyBase
Official Full Name: Lamin B receptorprovided by FlyBase
Primary source: FLYBASE:FBgn0034657
Locus tag: Dmel_CG17952
See related: AllianceGenome:FB:FBgn0034657
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17952; dLBR; Dmel\CG17952
Summary: Enables chromatin binding activity and lamin binding activity. Predicted to be involved in nucleus organization. Located in nuclear inner membrane. Is expressed in adult head; wing hinge primordium; and wing pouch. Human ortholog(s) of this gene implicated in Behcet's disease; Greenberg dysplasia; Pelger-Huet anomaly; Smith-Lemli-Opitz syndrome; and primary biliary cholangitis. Orthologous to several human genes including LBR (lamin B receptor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (21720495..21724055)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (17608000..17611560)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
NOT enables delta14-sterol reductase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables lamin binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables oxidoreductase activity	IKR Inferred from Key Residues more info	PubMed

Process	Evidence Code	Pubs
involved_in nucleus organization	IC Inferred by Curator more info	PubMed
involved_in sterol biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in nuclear inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear inner membrane	IDA Inferred from Direct Assay more info	PubMed

Names: CG17952-PA; CG17952-PB; CG17952-PC; LBR-PA; LBR-PB; LBR-PC; lamin-B receptor

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The following sections contain reference sequences that belong to a specific genome build. Explain