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    gzl godzilla E3 ubiquitin protein ligase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40791, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gzlprovided by FlyBase
    Official Full Name
    godzilla E3 ubiquitin protein ligaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037442
    Locus tag
    Dmel_CG10277
    See related
    AllianceGenome:FB:FBgn0037442
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10277; Dmel\CG10277; godzilla; godzilla[CG10277]
    Summary
    Enables ubiquitin protein ligase activity. Involved in endosomal transport; positive regulation of transcytosis; and protein ubiquitination. Located in endosome. Is expressed in adult head. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 73. Orthologous to human RNF13 (ring finger protein 13) and RNF167 (ring finger protein 167). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See gzl in Genome Data Viewer
    Location:
    83E5-83E5; 3-47.5 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6382914..6388304)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2208636..2214026)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Transcription factor IIFalpha Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Dementin Neighboring gene long non-coding RNA:CR44017 Neighboring gene grappa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. From Drosophila to Human: Biological Function of E3 Ligase Godzilla and Its Role in Disease. Cabana VC, et al. Cells, 2022 Jan 23. PMID 35159190, Free PMC Article
    2. Goliath family E3 ligases regulate the recycling endosome pathway via VAMP3 ubiquitylation. Yamazaki Y, et al. EMBO J, 2013 Feb 20. PMID 23353890, Free PMC Article
    3. Godzilla-dependent transcytosis promotes Wingless signalling in Drosophila wing imaginal discs. Yamazaki Y, et al. Nat Cell Biol, 2016 Apr. PMID 26974662, Free PMC Article
    4. Protein degradation of Lsd1 is mediated by Bre1 yet opposed by Lsd1-interacting lncRNAs during fly follicle development. Lin CT, et al. iScience, 2024 May 17. PMID 38655201, Free PMC Article
    5. Extensive translation of small Open Reading Frames revealed by Poly-Ribo-Seq. Aspden JL, et al. Elife, 2014 Aug 21. PMID 25144939, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. From Drosophila to Human: Biological Function of E3 Ligase Godzilla and Its Role in Disease.
      Title: From Drosophila to Human: Biological Function of E3 Ligase Godzilla and Its Role in Disease.
    2. Data show that Wingless transcytosis signaling requires Godzilla.
      Title: Godzilla-dependent transcytosis promotes Wingless signalling in Drosophila wing imaginal discs.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endosomal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    godzilla E3 ubiquitin protein ligase
    Names
    CG10277-PA
    CG10277-PB
    CG10277-PC
    CG10277-PD
    godzilla
    gzl-PA
    gzl-PB
    gzl-PC
    gzl-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      6382914..6388304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169139.2 → NP_731079.1  godzilla E3 ubiquitin protein ligase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731079.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T089, Q9VI20
      Related
      FBpp0081218
      Conserved Domains (2) summary
      cd02123
      Location:14 → 171
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      pfam13639
      Location:233 → 277
      zf-RING_2; Ring finger domain

    2. NM_001104225.2 → NP_001097695.1  godzilla E3 ubiquitin protein ligase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097695.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T089, Q9VI20
      Conserved Domains (2) summary
      cd02123
      Location:14 → 171
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      pfam13639
      Location:233 → 277
      zf-RING_2; Ring finger domain

    3. NM_141396.4 → NP_649653.1  godzilla E3 ubiquitin protein ligase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649653.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T089, Q9VI20
      Related
      FBpp0081217
      Conserved Domains (2) summary
      cd02123
      Location:14 → 171
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      pfam13639
      Location:233 → 277
      zf-RING_2; Ring finger domain

    4. NM_169140.2 → NP_731080.1  godzilla E3 ubiquitin protein ligase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731080.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T089, Q9VI20
      Related
      FBpp0081219
      Conserved Domains (2) summary
      cd02123
      Location:14 → 171
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      pfam13639
      Location:233 → 277
      zf-RING_2; Ring finger domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VI20.1 Q9VI20

    Gene LinkOut

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