Kdsr 3-ketodihydrosphingosine reductase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Kdsrprovided by FlyBase
Official Full Name: 3-ketodihydrosphingosine reductaseprovided by FlyBase
Primary source: FLYBASE:FBgn0039304
Locus tag: Dmel_CG10425
See related: AllianceGenome:FB:FBgn0039304
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10425; Dmel\CG10425
Summary: Predicted to enable 3-dehydrosphinganine reductase activity. Predicted to be involved in 3-keto-sphinganine metabolic process and sphingolipid biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic epipharynx; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis et progressiva 4 and follicular lymphoma. Orthologous to human KDSR (3-ketodihydrosphingosine reductase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (25260963..25262498, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (21086685..21088220, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 3-dehydrosphinganine reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-dehydrosphinganine reductase activity	IEA Inferred from Electronic Annotation more info
enables 3-dehydrosphinganine reductase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in 3-keto-sphinganine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 3-keto-sphinganine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sphingolipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingolipid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info

NP_651363.1

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The following sections contain reference sequences that belong to a specific genome build. Explain