U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Sil1 Sil1 nucleotide exchange factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43034, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Sil1provided by FlyBase
    Official Full Name
    Sil1 nucleotide exchange factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039296
    Locus tag
    Dmel_CG10420
    See related
    AllianceGenome:FB:FBgn0039296
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10420; Dmel\CG10420; SIL1
    Summary
    Predicted to enable adenyl-nucleotide exchange factor activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, translocation. Located in endomembrane system. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in primary cerebellar degeneration. Orthologous to human SIL1 (SIL1 nucleotide exchange factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Sil1 in Genome Data Viewer
    Location:
    96C7-96C7; 3-87 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25233636..25235529, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21059358..21061251, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ALG9, alpha-1,2-mannosyltransferase Neighboring gene Cadherin 96Cb Neighboring gene Juvenile hormone binding protein 7 Neighboring gene takeout

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing. Garelli A, et al. Nat Commun, 2015 Oct 29. PMID 26510564, Free PMC Article
    2. Muscleblind, BSF and TBPH are mislocalized in the muscle sarcomere of a Drosophila myotonic dystrophy model. Llamusi B, et al. Dis Model Mech, 2013 Jan. PMID 23118342, Free PMC Article
    3. Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin. Park SY, et al. Genetics, 2014 Feb. PMID 24281154, Free PMC Article
    4. Identification of Genes Involved in the Differentiation of R7y and R7p Photoreceptor Cells in Drosophila. Earl JB, et al. G3 (Bethesda), 2020 Nov 5. PMID 32972998, Free PMC Article
    5. Expression profiling of a hypercontraction-induced myopathy in Drosophila suggests a compensatory cytoskeletal remodeling response. Montana ES, et al. J Biol Chem, 2006 Mar 24. PMID 16415344

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Sil1 nucleotide exchange factor
    Names
    CG10420-PA
    Sil1-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25233636..25235529 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143099.4 → NP_651356.1  Sil1 nucleotide exchange factor [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651356.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VBV5
      Related
      FBpp0084244
      Conserved Domains (1) summary
      pfam16782
      Location:167 → 326
      SIL1; Nucleotide exchange factor SIL1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBV5.1 Q9VBV5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools