Vps29 Vacuolar protein sorting 29 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Vps29provided by FlyBase
Official Full Name: Vacuolar protein sorting 29provided by FlyBase
Primary source: FLYBASE:FBgn0031310
Locus tag: Dmel_CG4764
See related: AllianceGenome:FB:FBgn0031310
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4764; Dmel\CG4764; DmVps29; VPS29
Summary: Involved in regulation of synaptic vesicle endocytosis. Located in late endosome membrane. Is active in neuromuscular junction. Is expressed in adult head; adult heart; embryonic/larval garland cell; garland cell primordium; and organism. Orthologous to human VPS29 (VPS29 retromer complex component). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (1150766..1151764)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (1150766..1151764)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain.
Title: Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic vesicle endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde transport, endosome to Golgi	IEA Inferred from Electronic Annotation more info
involved_in retrograde transport, endosome to Golgi	ISS Inferred from Sequence or Structural Similarity more info
involved_in symbiont entry into host cell	HMP more info	PubMed

Component	Evidence Code	Pubs
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in late endosome membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
part_of retromer complex	IBA Inferred from Biological aspect of Ancestor more info
part_of retromer complex	IEA Inferred from Electronic Annotation more info
part_of retromer, cargo-selective complex	ISS Inferred from Sequence or Structural Similarity more info

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The following sections contain reference sequences that belong to a specific genome build. Explain