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    CG3376 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37884, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG3376provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034997
    Locus tag
    Dmel_CG3376
    See related
    AllianceGenome:FB:FBgn0034997
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    aSMase; Dmel\CG3376
    Summary
    Predicted to enable sphingomyelin phosphodiesterase activity. Involved in liquid clearance, open tracheal system. Located in extracellular space and lysosome. Is expressed in several structures, including embryonic epipharynx; embryonic head epidermis; epithelium; gut section; and larval muscle cell. Human ortholog(s) of this gene implicated in Niemann-Pick disease; Niemann-Pick disease type A; and Niemann-Pick disease type B. Orthologous to human SMPD1 (sphingomyelin phosphodiesterase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3376 in Genome Data Viewer
    Location:
    60C4-60C4; 2-106 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24258013..24265213)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20145536..20152736)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene nord Neighboring gene Ionotropic receptor 60a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene nervy

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endogenous ceramide phosphoethanolamine modulates circadian rhythm via neural-glial coupling in Drosophila. Chen X, et al. Natl Sci Rev, 2022 Dec. PMID 36713590, Free PMC Article
    2. CLOCKWORK ORANGE promotes CLOCK-CYCLE activation via the putative Drosophila ortholog of CLOCK INTERACTING PROTEIN CIRCADIAN. Rivas GBS, et al. Curr Biol, 2021 Oct 11. PMID 34331859, Free PMC Article
    3. A surfactant lipid layer of endosomal membranes facilitates airway gas filling in Drosophila. Tsarouhas V, et al. Curr Biol, 2023 Dec 4. PMID 37992718
    4. An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms. Kanca O, et al. Elife, 2019 Nov 1. PMID 31674908, Free PMC Article
    5. Metabolism of sphingosine 1-phosphate and lysophosphatidic acid: a genome wide analysis of gene expression in Drosophila. Renault AD, et al. Mech Dev, 2002 Dec. PMID 14516700

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acid sphingomyelin phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sphingomyelin phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in liquid clearance, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingomyelin catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingomyelin catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3376-PA
    CG3376-PB
    CG3376-PC
    CG3376-PD
    NP_001246491.1
    NP_001286833.1
    NP_611904.1
    NP_726435.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24258013..24265213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166665.2 → NP_726435.1  uncharacterized protein Dmel_CG3376, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726435.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MLP3
      Related
      FBpp0072172
      Conserved Domains (3) summary
      smart00741
      Location:157 → 229
      SapB; Saposin (B) Domains
      cd00842
      Location:272 → 571
      MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain
      pfam00149
      Location:270 → 534
      Metallophos; Calcineurin-like phosphoesterase

    2. NM_001299904.1 → NP_001286833.1  uncharacterized protein Dmel_CG3376, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286833.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGL2
      Conserved Domains (3) summary
      smart00741
      Location:157 → 229
      SapB; Saposin (B) Domains
      cd00842
      Location:272 → 571
      MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain
      pfam00149
      Location:270 → 534
      Metallophos; Calcineurin-like phosphoesterase

    3. NM_138060.3 → NP_611904.1  uncharacterized protein Dmel_CG3376, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611904.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W188
      Related
      FBpp0072173
      Conserved Domains (3) summary
      smart00741
      Location:157 → 229
      SapB; Saposin (B) Domains
      cd00842
      Location:272 → 571
      MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain
      pfam00149
      Location:270 → 534
      Metallophos; Calcineurin-like phosphoesterase

    4. NM_001259562.1 → NP_001246491.1  uncharacterized protein Dmel_CG3376, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246491.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D6W4U0
      Conserved Domains (3) summary
      smart00741
      Location:186 → 258
      SapB; Saposin (B) Domains
      cd00842
      Location:301 → 600
      MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain
      pfam00149
      Location:299 → 563
      Metallophos; Calcineurin-like phosphoesterase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGL2 A0A0B4LGL2
    D6W4U0 D6W4U0
    Q8MLP3 Q8MLP3
    Q95T74 Q95T74
    Q9W188 Q9W188

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