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    CG5946 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39336, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5946provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036211
    Locus tag
    Dmel_CG5946
    See related
    AllianceGenome:FB:FBgn0036211
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5946
    Summary
    Predicted to enable FAD binding activity and cytochrome-b5 reductase activity, acting on NAD(P)H. Involved in regulation of lipid storage. Located in endomembrane system. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in breast cancer and methemoglobinemia. Orthologous to several human genes including CYB5R3 (cytochrome b5 reductase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5946 in Genome Data Viewer
    Location:
    68E1-68E1; 3-37 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11816695..11822275, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11809795..11815375, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Glutamine-TTG 1-1 Neighboring gene Cubilin 2 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L10Ab Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytochrome b5 reductase: the roles of the recessive congenital methemoglobinemia mutants P144L, L148P, and R159*. Davis CA, et al. Arch Biochem Biophys, 2004 Nov 15. PMID 15488472
    2. Systems genetics analysis of body weight and energy metabolism traits in Drosophila melanogaster. Jumbo-Lucioni P, et al. BMC Genomics, 2010 May 11. PMID 20459830, Free PMC Article
    3. COPI complex is a regulator of lipid homeostasis. Beller M, et al. PLoS Biol, 2008 Nov 25. PMID 19067489, Free PMC Article
    4. The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity. Fox RM, et al. J Cell Biol, 2010 Nov 1. PMID 21041443, Free PMC Article
    5. Quantitative Proteomic Analyses of Molecular Mechanisms Associated with Cytoplasmic Incompatibility in Drosophila melanogaster Induced by Wolbachia. Yuan LL, et al. J Proteome Res, 2015 Sep 4. PMID 26220534

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables FAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytochrome-b5 reductase activity, acting on NAD(P)H ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPI vesicle coat ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endomembrane system HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5946-PA
    CG5946-PB
    CG5946-PC
    CG5946-PD
    CG5946-PE
    CG5946-PF
    CG5946-PG
    NP_001036600.1
    NP_001036601.1
    NP_001163421.1
    NP_001163422.1
    NP_001287035.1
    • unusual splice
    NP_648512.2
    NP_729751.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11816695..11822275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140255.4 → NP_648512.2  uncharacterized protein Dmel_CG5946, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648512.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4LDP7, Q95T90
      Related
      FBpp0075810
      Conserved Domains (2) summary
      cd06183
      Location:59 → 316
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      PTZ00319
      Location:51 → 316
      PTZ00319; NADH-cytochrome B5 reductase; Provisional

    2. NM_001169950.1 → NP_001163421.1  uncharacterized protein Dmel_CG5946, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163421.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHY0, Q95T90
      Conserved Domains (1) summary
      cd06183
      Location:59 → 260
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

    3. NM_001169951.2 → NP_001163422.1  uncharacterized protein Dmel_CG5946, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163422.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4LDP7, Q95T90
      Conserved Domains (2) summary
      cd06183
      Location:59 → 316
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      PTZ00319
      Location:51 → 316
      PTZ00319; NADH-cytochrome B5 reductase; Provisional

    4. NM_168479.3 → NP_729751.1  uncharacterized protein Dmel_CG5946, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729751.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IH41, Q95T90, Q9I7R1, Q9VTP2
      Related
      FBpp0075811
      Conserved Domains (2) summary
      cd06183
      Location:56 → 313
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      PTZ00319
      Location:48 → 313
      PTZ00319; NADH-cytochrome B5 reductase; Provisional

    5. NM_001043135.3 → NP_001036600.1  uncharacterized protein Dmel_CG5946, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036600.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8F5, Q95T90
      Conserved Domains (2) summary
      cd06183
      Location:59 → 316
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      PTZ00319
      Location:51 → 316
      PTZ00319; NADH-cytochrome B5 reductase; Provisional

    6. NM_001300106.1 → NP_001287035.1  uncharacterized protein Dmel_CG5946, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287035.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JGK6
      Conserved Domains (2) summary
      cd06183
      Location:59 → 330
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      PTZ00319
      Location:51 → 330
      PTZ00319; NADH-cytochrome B5 reductase; Provisional

    7. NM_001043136.2 → NP_001036601.1  uncharacterized protein Dmel_CG5946, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036601.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8F4, Q95T90
      Conserved Domains (2) summary
      cd06183
      Location:56 → 313
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      PTZ00319
      Location:48 → 313
      PTZ00319; NADH-cytochrome B5 reductase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JHY0 E1JHY0
    Q0E8F4 Q0E8F4
    Q0E8F5 Q0E8F5
    Q4LDP7 Q4LDP7
    Q95T90 Q95T90
    Q9I7R1 Q9I7R1
    X2JGK6 X2JGK6

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