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    Nubpl NUBP iron-sulfur cluster assembly factor, mitochondrial [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35452, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nubplprovided by FlyBase
    Official Full Name
    NUBP iron-sulfur cluster assembly factor, mitochondrialprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032986
    Locus tag
    Dmel_CG3262
    See related
    AllianceGenome:FB:FBgn0032986
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3262; Dmel\CG3262; NUBPL
    Summary
    Enables iron-sulfur cluster binding activity and phospholipid binding activity. Predicted to be involved in iron-sulfur cluster assembly and mitochondrial respiratory chain complex I assembly. Is active in mitochondrion. Is expressed in adult head. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 21. Orthologous to human NUBPL (NUBP iron-sulfur cluster assembly factor, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nubpl in Genome Data Viewer
    Location:
    40F6-40F6; 2-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (22239916..22246988)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (22239916..22246988)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Microsomal glutathione S-transferase-like pseudogene Neighboring gene long non-coding RNA:CR43765 Neighboring gene Ribosomal protein L21 Neighboring gene Tif-IA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Implications of Membrane Binding by the Fe-S Cluster-Containing N-Terminal Domain in the Drosophila Mitochondrial Replicative DNA Helicase. So M, et al. Front Genet, 2021. PMID 34950192, Free PMC Article
    2. Protein phosphatase 2A interacts with Verthandi/Rad21 to regulate mitosis and organ development in Drosophila. Kim LH, et al. Sci Rep, 2019 May 20. PMID 31110215, Free PMC Article
    3. A single double-strand break system reveals repair dynamics and mechanisms in heterochromatin and euchromatin. Janssen A, et al. Genes Dev, 2016 Jul 15. PMID 27474442, Free PMC Article
    4. Maintenance of Cell Fate by the Polycomb Group Gene Sex Combs Extra Enables a Partial Epithelial Mesenchymal Transition in Drosophila. Jefferies G, et al. G3 (Bethesda), 2020 Dec 3. PMID 33051260, Free PMC Article
    5. dCas9-targeted locus-specific protein isolation method identifies histone gene regulators. Tsui C, et al. Proc Natl Acad Sci U S A, 2018 Mar 20. PMID 29507191, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 22241337-22241757 mobile_element_type = transposon:jockey{}6056
    • Loc: 22241899-22242143 mobile_element_type = transposon:INE-1{}6153
    • Loc: 22245573-22245836 mobile_element_type = transposon:invader1{}2036

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent FeS chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron-sulfur cluster assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NUBP iron-sulfur cluster assembly factor, mitochondrial
    Names
    CG3262-PD
    CG3262-PE
    CG3262-PF
    Nubpl-PD
    Nubpl-PE
    Nubpl-PF
    nucleotide-binding protein-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      22239916..22246988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273759.1 → NP_001260688.1  NUBP iron-sulfur cluster assembly factor, mitochondrial, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260688.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C4IY21, Q8SZU4, Q9V9M8
      Conserved Domains (2) summary
      TIGR01969
      Location:41 → 281
      minD_arch; cell division ATPase MinD, archaeal
      pfam10609
      Location:37 → 275
      ParA; NUBPL iron-transfer P-loop NTPase

    2. NM_136299.5 → NP_610143.3  NUBP iron-sulfur cluster assembly factor, mitochondrial, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610143.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C4IY21, Q8SZU4, Q9V9M8
      Conserved Domains (2) summary
      TIGR01969
      Location:41 → 281
      minD_arch; cell division ATPase MinD, archaeal
      pfam10609
      Location:37 → 275
      ParA; NUBPL iron-transfer P-loop NTPase

    3. NM_165412.3 → NP_724389.1  NUBP iron-sulfur cluster assembly factor, mitochondrial, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724389.1

      Status: REVIEWED

      Related
      FBpp0306286
      Conserved Domains (1) summary
      cl21455
      Location:1 → 189
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZU4 Q8SZU4
    Q9V9M8 Q9V9M8

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