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    Sas10 Something about silencing 10 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31447, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sas10provided by FlyBase
    Official Full Name
    Something about silencing 10provided by FlyBase
    Primary source
    FLYBASE:FBgn0029755
    Locus tag
    Dmel_CG4202
    See related
    AllianceGenome:FB:FBgn0029755
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4202; Dmel\CG4202; dSAS10; l(1)G0106; sas-10; sas10
    Summary
    Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in several structures, including amnioproctodeal invagination; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; ganglia; and mesoderm. Orthologous to human UTP3 (UTP3 small subunit processome component). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sas10 in Genome Data Viewer
    Location:
    4F5-4F5; 1-11 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5317409..5319071)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5211442..5213104)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene deadhead Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene RNA-binding protein 4F Neighboring gene Minichromosome maintenance 3 Neighboring gene uncharacterized protein Neighboring gene XRCC1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNA editing and regulation of Drosophila 4f-rnp expression by sas-10 antisense readthrough mRNA transcripts. Peters NT, et al. RNA, 2003 Jun. PMID 12756328, Free PMC Article
    2. Alternative splicing of an rnp-4f mRNA isoform retaining an evolutionarily-conserved 5'-UTR intronic element is developmentally regulated and shown via RNAi to be essential for normal central nervous system development in Drosophila melanogaster. Chen J, et al. Gene, 2007 Sep 15. PMID 17582706
    3. Mcm3 replicative helicase mutation impairs neuroblast proliferation and memory in Drosophila. Blumröder R, et al. Genes Brain Behav, 2016 Sep. PMID 27283469, Free PMC Article
    4. The Spliceosomal Protein SF3B5 is a Novel Component of Drosophila SAGA that Functions in Gene Expression Independent of Splicing. Stegeman R, et al. J Mol Biol, 2016 Sep 11. PMID 27185460, Free PMC Article
    5. Functional genomics identifies TOR-regulated genes that control growth and division. Guertin DA, et al. Curr Biol, 2006 May 23. PMID 16713952

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNA editing and regulation of 4f-rnp expression by sas-10 antisense readthrough mRNA transcripts.
      Title: RNA editing and regulation of Drosophila 4f-rnp expression by sas-10 antisense readthrough mRNA transcripts.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    something about silencing 10
    Names
    CG4202-PA
    Sas10-PA
    something about silencing 10 ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5317409..5319071
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_131987.4 → NP_572215.1  something about silencing 10 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572215.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q961T6, Q9I7W5
      Related
      FBpp0070719
      Conserved Domains (2) summary
      pfam04000
      Location:191 → 269
      Sas10_Utp3; Sas10/Utp3/C1D family
      pfam09368
      Location:354 → 426
      Sas10; Sas10 C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I7W5.2 Q9I7W5

    Gene LinkOut

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