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    eater eater [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43262, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eaterprovided by FlyBase
    Official Full Name
    eaterprovided by FlyBase
    Primary source
    FLYBASE:FBgn0243514
    Locus tag
    Dmel_CG6124
    See related
    AllianceGenome:FB:FBgn0243514
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    C901-like; CG6124; CT19227; Dmel\CG6124; Dmel_CG6124; Eater
    Summary
    Enables peptidoglycan binding activity and scavenger receptor activity. Involved in several processes, including defense response to Gram-positive bacterium; phagocytosis, recognition; and positive regulation of phagocytosis. Located in cell surface. Is expressed in several structures, including cortical zone of lymph gland primary lobe; embryonic/larval lymph gland; hemocyte; and prohemocyte. Used to study bacterial infectious disease. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eater in Genome Data Viewer
    Location:
    97E2-97E2; 3-92 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27095867..27099679, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22921589..22925401, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Juvenile hormone binding protein 11 Neighboring gene Carbonic anhydrase 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recognition of pathogenic microbes by the Drosophila phagocytic pattern recognition receptor Eater. Chung YS, et al. J Biol Chem, 2011 Jul 29. PMID 21613218, Free PMC Article
    2. Phagocytosis of bacterial pathogens. Chung YS, et al. Fly (Austin), 2012 Jan-Mar. PMID 22223092, Free PMC Article
    3. Haplotype structure and expression divergence at the Drosophila cellular immune gene eater. Juneja P, et al. Mol Biol Evol, 2010 Oct. PMID 20444883, Free PMC Article
    4. The fliR gene contributes to the virulence of S. marcescens in a Drosophila intestinal infection model. Sina Rahme B, et al. Sci Rep, 2022 Feb 23. PMID 35197500, Free PMC Article
    5. Drosophila immune priming to Enterococcus faecalis relies on immune tolerance rather than resistance. Cabrera K, et al. PLoS Pathog, 2023 Aug. PMID 37566589, Free PMC Article

    See all (121) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Eater cooperates with Multiplexin to drive the formation of hematopoietic compartments.
      Title: Eater cooperates with Multiplexin to drive the formation of hematopoietic compartments.
    2. Rsults suggest that cationic antimicrobial peptides, as well as lysozymes, can facilitate Eater binding to live Gram-negative bacteria.
      Title: Phagocytosis of bacterial pathogens.
    3. Serpent regulates eater expression by binding to GATA sites.
      Title: Transcriptional regulation of eater gene expression in Drosophila blood cells.
    4. Recognition of pathogenic microbes by the Drosophila phagocytic pattern recognition receptor Eater.
      Title: Recognition of pathogenic microbes by the Drosophila phagocytic pattern recognition receptor Eater.
    5. CG6124 is the newly-named gene, eater. It is a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila.
      Title: Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables peptidoglycan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables scavenger receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phagocytosis, recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell-substrate adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eater
    Names
    CG6124-PC
    eater-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27095867..27099679 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143276.3 → NP_651533.3  eater [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651533.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VB78
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VB78 Q9VB78

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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