U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Dtwd2 DTW domain containing 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40873, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Dtwd2provided by FlyBase
    Official Full Name
    DTW domain containing 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0037492
    Locus tag
    Dmel_CG10050
    See related
    AllianceGenome:FB:FBgn0037492
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10050; Dmel\CG10050; DTWD2; DTWD2A
    Summary
    Enables tRNA-uridine aminocarboxypropyltransferase activity. Involved in tRNA modification. Predicted to be active in cytosol. Is expressed in anterior midgut primordium; organism; pole plasm; posterior midgut primordium; and spermatozoon. Orthologous to human DTWD2 (DTW domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Dtwd2 in Genome Data Viewer
    Location:
    84D3-84D3; 3-48 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7249795..7251750)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3075517..3077472)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Odorant-binding protein 84a Neighboring gene Glucose dehydrogenase Neighboring gene long non-coding RNA:CR44338 Neighboring gene Synaptotagmin 4

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of the enzymes responsible for m2,2G and acp3U formation on cytosolic tRNA from insects and plants. Funk HM, et al. PLoS One, 2020. PMID 33253256, Free PMC Article
    2. An RNA-seq screen of the Drosophila antenna identifies a transporter necessary for ammonia detection. Menuz K, et al. PLoS Genet, 2014 Nov. PMID 25412082, Free PMC Article
    3. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article
    4. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables tRNA-uridine aminocarboxypropyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tRNA modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    DTW domain containing 2
    Names
    CG10050-PA
    Dtwd2-PA
    NP_649713.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7249795..7251750
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141456.4 → NP_649713.1  DTW domain containing 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649713.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VI85
      UniProtKB/TrEMBL
      A8E6X1
      Related
      FBpp0081096
      Conserved Domains (1) summary
      pfam03942
      Location:20 → 209
      DTW; DTW domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VI85.1 Q9VI85

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools