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    Vha14-2 Vacuolar H[+] ATPase 14kD subunit 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40748, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vha14-2provided by FlyBase
    Official Full Name
    Vacuolar H[+] ATPase 14kD subunit 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0037402
    Locus tag
    Dmel_CG1076
    See related
    AllianceGenome:FB:FBgn0037402
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1076; Dmel\CG1076; Vha14; vha14-2
    Summary
    Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Predicted to be part of proton-transporting V-type ATPase complex. Predicted to be active in membrane. Orthologous to human ATP6V1F (ATPase H+ transporting V1 subunit F). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Vha14-2 in Genome Data Viewer
    Location:
    83D4-83D4; 3-47.5 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6122592..6124405)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1948314..1950127)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Odorant-binding protein 83cd Neighboring gene Odorant-binding protein 83ef Neighboring gene Odorant-binding protein 83g Neighboring gene long non-coding RNA:CR43486 Neighboring gene long non-coding RNA:CR43487

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Histone deacetylase-mediated regulation of endolysosomal pH. Prasad H, et al. J Biol Chem, 2018 May 4. PMID 29567836, Free PMC Article
    2. Genome-wide survey of V-ATPase genes in Drosophila reveals a conserved renal phenotype for lethal alleles. Allan AK, et al. Physiol Genomics, 2005 Jul 14. PMID 15855386
    3. Early-life nutrition interacts with developmental genes to shape the brain and sleep behavior in Drosophila melanogaster. Olivares GH, et al. Sleep, 2023 Apr 12. PMID 36718043
    4. Data-mining the FlyAtlas online resource to identify core functional motifs across transporting epithelia. Chintapalli VR, et al. BMC Genomics, 2013 Jul 30. PMID 23895496, Free PMC Article
    5. Intestinal response to dietary manganese depletion in Drosophila. Vásquez-Procopio J, et al. Metallomics, 2020 Feb 1. PMID 31799578

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proton transmembrane transport IC
    Inferred by Curator
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proton-transporting V-type ATPase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of proton-transporting V-type ATPase, V1 domain IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar H[+] ATPase 14kD subunit 2
    Names
    CG1076-PA
    CG1076-PB
    CG1076-PC
    Vha14-2-PA
    Vha14-2-PB
    Vha14-2-PC
    vacuolar H[+] ATPase subunit 14-2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      6122592..6124405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260015.1 → NP_001246944.1  vacuolar H[+] ATPase 14kD subunit 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246944.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K626
      Conserved Domains (1) summary
      cl00632
      Location:9 → 119
      ATP-synt_F; ATP synthase (F/14-kDa) subunit

    2. NM_141357.2 → NP_649614.1  vacuolar H[+] ATPase 14kD subunit 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649614.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VNL3
      Related
      FBpp0078234
      Conserved Domains (1) summary
      cl00632
      Location:51 → 124
      ATP-synt_F; ATP synthase (F/14-kDa) subunit

    3. NM_001260014.1 → NP_001246943.1  vacuolar H[+] ATPase 14kD subunit 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246943.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K626
      Conserved Domains (1) summary
      cl00632
      Location:9 → 119
      ATP-synt_F; ATP synthase (F/14-kDa) subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K626 A0A0B4K626
    Q9VNL3.2 Q9VNL3

    Gene LinkOut

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