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    Cubn2 Cubilin 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39334, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cubn2provided by FlyBase
    Official Full Name
    Cubilin 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0259140
    Locus tag
    Dmel_CG42255
    See related
    AllianceGenome:FB:FBgn0259140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32092; CG32094; CG42255; CG5956; CT18701; Cubn-2; Dmel\CG42255
    Old locus tag
    Dmel_CG32092; Dmel_CG32094
    Summary
    Enables cargo receptor activity. Involved in clathrin-dependent endocytosis and renal protein absorption. Located in cytosol. Part of receptor complex. Is expressed in several structures, including adult brain cell body rind; adult head; adult heart; embryonic/larval garland cell; and garland cell primordium. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human CUBN (cubilin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cubn2 in Genome Data Viewer
    Location:
    68E1-68E1; 3-37 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11801951..11814755, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11795051..11807855, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Glutamine-TTG 1-1 Neighboring gene Glycine C-acetyltransferase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endocytosis mediated by an atypical CUBAM complex modulates slit diaphragm dynamics in nephrocytes. Atienza-Manuel A, et al. Development, 2021 Nov 15. PMID 34738617, Free PMC Article
    2. Subdivision and developmental fate of the head mesoderm in Drosophila melanogaster. de Velasco B, et al. Dev Genes Evol, 2006 Jan. PMID 16249873
    3. Bioinformatic analysis suggests potential mechanisms underlying parasitoid venom evolution and function. Alvarado G, et al. Genomics, 2020 Mar. PMID 31247332
    4. Using Drosophila Nephrocytes to Understand the Formation and Maintenance of the Podocyte Slit Diaphragm. van de Leemput J, et al. Front Cell Dev Biol, 2022. PMID 35265622, Free PMC Article
    5. Insights into human kidney function from the study of Drosophila. Koehler S, et al. Pediatr Nephrol, 2023 Dec. PMID 37171583, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cargo receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in renal protein absorption IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    part_of receptor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cubilin 2
    Names
    CG42255-PB
    Cubilin2
    Cubn2-PB
    cubulin 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11801951..11814755 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168477.3 → NP_729748.3  cubilin 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729748.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTP0
      Conserved Domains (5) summary
      smart00179
      Location:290 → 328
      EGF_CA; Calcium-binding EGF-like domain
      cd00041
      Location:1066 → 1179
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00054
      Location:192 → 233
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:427 → 455
      EGF; EGF-like domain
      cl00049
      Location:2688 → 2782
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTP0 Q9VTP0

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