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    CG10505 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37428, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10505provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034612
    Locus tag
    Dmel_CG10505
    See related
    AllianceGenome:FB:FBgn0034612
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    DmCG10505; Dmel\CG10505; Dme_CG10505
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in response to copper ion and response to zinc ion. Predicted to be active in membrane. Is expressed in adult head and spermatozoon. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10505 in Genome Data Viewer
    Location:
    57D7-57D8; 2-94 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21285248..21290343, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17172753..17177848, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Rad, Gem/Kir family member 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Major Facilitator Superfamily Transporter 16 Neighboring gene uncharacterized protein Neighboring gene SAGA-associated factor 29kDa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila as a model for studying cystic fibrosis pathophysiology of the gastrointestinal system. Kim K, et al. Proc Natl Acad Sci U S A, 2020 May 12. PMID 32345720, Free PMC Article
    2. Transcriptomic and functional genetic evidence for distinct ecophysiological responses across complex life cycle stages. Freda PJ, et al. J Exp Biol, 2022 Jun 1. PMID 35578907
    3. The dMRP/CG6214 gene of Drosophila is evolutionarily and functionally related to the human multidrug resistance-associated protein family. Tarnay JN, et al. Insect Mol Biol, 2004 Oct. PMID 15373810
    4. Genetic variation in the shape of cold-survival curves in a single fly population suggests potential for selection from climate variability. Teets NM, et al. J Evol Biol, 2018 Apr. PMID 29345010
    5. Characterizing the genetic basis of copper toxicity in Drosophila reveals a complex pattern of allelic, regulatory, and behavioral variation. Everman ER, et al. Genetics, 2021 Mar 3. PMID 33683361, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to copper ion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to zinc ion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    ABC transporter
    CG10505-PA
    NP_611571.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21285248..21290343 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137727.3 → NP_611571.2  uncharacterized protein Dmel_CG10505 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611571.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      F9W327, Q9W2I5
      Conserved Domains (4) summary
      cd03244
      Location:1045 → 1264
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:428 → 632
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      TIGR01271
      Location:12 → 1268
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl00549
      Location:728 → 994
      ABC_membrane; ABC transporter transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W2I5 Q9W2I5

    Gene LinkOut

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