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    maf-S maf-S [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37336, updated on 27-Dec-2024

    Summary

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    Official Symbol
    maf-Sprovided by FlyBase
    Official Full Name
    maf-Sprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034534
    Locus tag
    Dmel_CG9954
    See related
    AllianceGenome:FB:FBgn0034534
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey173; CG9954; DM19; DM31; Dmel\CG9954; maf; Maf; Maf-S; MAF-S; maf2; mafs; mafS; MafS
    Summary
    Enables protein heterodimerization activity. Contributes to DNA-binding transcription factor activity. Involved in head development and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including anterior endoderm; central brain primordium; cephalic furrow; embryonic/larval midgut primordium; and ganglia. Orthologous to several human genes including MAFK (MAF bZIP transcription factor K). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See maf-S in Genome Data Viewer
    Location:
    57A8-57A8; 2-91 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20640976..20641668)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16528481..16529173)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Family with sequence similarity 21 Neighboring gene Reduction in Cnn dots 6 Neighboring gene rigor mortis Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene RNA polymerase III subunit K Neighboring gene Threonyl-carbamoyl synthesis 1 Neighboring gene DNA methyltransferase 1 associated protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and cloning of a Drosophila homolog to the mammalian RACK1 gene, implicated in PKC-mediated signalling. Vani K, et al. Biochim Biophys Acta, 1997 Aug 21. PMID 9296523
    2. Assessing neurodegenerative phenotypes in Drosophila dopaminergic neurons by climbing assays and whole brain immunostaining. Barone MC, et al. J Vis Exp, 2013 Apr 24. PMID 23644755, Free PMC Article
    3. Mechanisms and functions of Nrf2 signaling in Drosophila. Pitoniak A, et al. Free Radic Biol Med, 2015 Nov. PMID 26117322, Free PMC Article
    4. Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease. Barone MC, et al. Dis Model Mech, 2011 Sep. PMID 21719443, Free PMC Article
    5. Cap 'n' collar B cooperates with a small Maf subunit to specify pharyngeal development and suppress deformed homeotic function in the Drosophila head. Veraksa A, et al. Development, 2000 Sep. PMID 10952900

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in head development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    maf-S
    Names
    CG9954-PA
    CG9954-PB
    maf-S-PA
    maf-S-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20640976..20641668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299710.1 → NP_001286639.1  maf-S, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286639.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LH09
      Conserved Domains (1) summary
      cd14717
      Location:51 → 120
      bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

    2. NM_137656.4 → NP_611500.1  maf-S, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611500.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4QPP9
      Related
      FBpp0085544
      Conserved Domains (1) summary
      cd14717
      Location:46 → 115
      bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LH09 A0A0B4LH09
    Q4QPP9 Q4QPP9

    Gene LinkOut

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