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    Stacl Stac-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740318, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Staclprovided by FlyBase
    Official Full Name
    Stac-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263980
    Locus tag
    Dmel_CG43729
    See related
    AllianceGenome:FB:FBgn0263980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12958; CG12959; CG14163; CG18625; CG30470; CG34318; CG34365; CG43223; CG43729; CG8179; Dmel\CG43729; Dm_2R:47664; Dm_2R:47672; Dstac; mdcds_11908
    Old locus tag
    CG12958; CG12959; CG18625; CG8179; Dmel_CG12958; Dmel_CG12959; Dmel_CG18625; Dmel_CG30470; Dmel_CG34318; Dmel_CG34365; Dmel_CG43223; Dmel_CG8179
    Summary
    Enables calcium channel regulator activity. Involved in calcium ion transmembrane transport; locomotion; and positive regulation of cell size. Human ortholog(s) of this gene implicated in Native American myopathy. Orthologous to human STAC (SH3 and cysteine rich domain); STAC2 (SH3 and cysteine rich domain 2); and STAC3 (SH3 and cysteine rich domain 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Stacl in Genome Data Viewer
    Location:
    51F13-52A4; 2-74 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15401096..15471884)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11288601..11359389)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene double parked Neighboring gene SR Protein Kinase Neighboring gene long non-coding RNA:CR45020 Neighboring gene Metchnikowin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dstac is required for normal circadian activity rhythms in Drosophila. Hsu IU, et al. Chronobiol Int, 2018 Jul. PMID 29621409, Free PMC Article
    2. Dstac Regulates Excitation-Contraction Coupling in Drosophila Body Wall Muscles. Hsu IU, et al. Front Physiol, 2020. PMID 33123029, Free PMC Article
    3. Stac protein regulates release of neuropeptides. Hsu IU, et al. Proc Natl Acad Sci U S A, 2020 Nov 24. PMID 33168737, Free PMC Article
    4. A microRNA that controls the emergence of embryonic movement. Menzies JAC, et al. Elife, 2024 Jun 13. PMID 38869942, Free PMC Article
    5. A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1. Cully M, et al. Mol Cell Biol, 2010 Jan. PMID 19917724, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium channel regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell size IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Stac-like
    Names
    CG43729-PA
    CG43729-PC
    CG43729-PE
    CG43729-PH
    CG43729-PI
    CG43729-PJ
    CG43729-PM
    CG43729-PN
    CG43729-PO
    CG43729-PP
    CG43729-PQ
    CG43729-PR
    CG43729-PS
    CG43729-PT
    CG43729-PU
    CG43729-PV
    CG43729-PW
    CG43729-PX
    Stacl-PA
    Stacl-PC
    Stacl-PE
    Stacl-PH
    Stacl-PI
    Stacl-PJ
    Stacl-PM
    Stacl-PN
    Stacl-PO
    Stacl-PP
    Stacl-PQ
    Stacl-PR
    Stacl-PS
    Stacl-PT
    Stacl-PU
    Stacl-PV
    Stacl-PW
    Stacl-PX

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15401096..15471884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274065.2 → NP_001260994.1  Stac-like, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260994.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KG20
      Conserved Domains (3) summary
      cd00029
      Location:727 → 773
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl12013
      Location:290 → 489
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:1051 → 1102
      SH3; Src Homology 3 domain superfamily

    2. NM_001274066.1 → NP_001260995.1  Stac-like, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260995.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFR2
      Conserved Domains (3) summary
      cd00029
      Location:727 → 773
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl12013
      Location:290 → 489
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:1051 → 1102
      SH3; Src Homology 3 domain superfamily

    3. NM_001274067.1 → NP_001260996.1  Stac-like, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260996.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEV7
      Conserved Domains (3) summary
      cd00029
      Location:727 → 773
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl12013
      Location:290 → 489
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:1051 → 1102
      SH3; Src Homology 3 domain superfamily

    4. NM_001299528.1 → NP_001286457.1  Stac-like, isoform V [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286457.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGK0
      Conserved Domains (3) summary
      cd00029
      Location:708 → 754
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl12013
      Location:290 → 489
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:1083 → 1134
      SH3; Src Homology 3 domain superfamily

    5. NM_001274068.2 → NP_001260997.2  Stac-like, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260997.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KER3
      Conserved Domains (3) summary
      cd00029
      Location:708 → 754
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl12013
      Location:290 → 489
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:1041 → 1092
      SH3; Src Homology 3 domain superfamily

    6. NM_001299527.1 → NP_001286456.1  Stac-like, isoform U [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286456.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFI1
      Conserved Domains (3) summary
      cd00029
      Location:708 → 754
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl12013
      Location:290 → 489
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:974 → 1025
      SH3; Src Homology 3 domain superfamily

    7. NM_001382114.1 → NP_001369089.1  Stac-like, isoform X [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3QAK8
      Conserved Domains (5) summary
      PHA03247
      Location:20 → 283
      PHA03247; large tegument protein UL36; Provisional
      cd22250
      Location:793 → 848
      ROCK_SBD; Shroom-binding domain found in Rho-associated coiled-coil containing protein kinase
      cd20817
      Location:920 → 970
      C1_Stac; protein kinase C conserved region 1 (C1 domain) found in the SH3 and cysteine-rich domain-containing protein (Stac) family
      cl12013
      Location:502 → 701
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:1253 → 1304
      SH3; Src Homology 3 domain superfamily

    8. NM_001299525.1 → NP_001286454.1  Stac-like, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286454.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LF79
      Conserved Domains (2) summary
      cd00029
      Location:708 → 754
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl12013
      Location:290 → 489
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    9. NM_001103855.4 → NP_001097325.2  Stac-like, isoform T [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097325.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYE4
      Conserved Domains (1) summary
      cd00029
      Location:708 → 754
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    10. NM_001274069.2 → NP_001260998.2  Stac-like, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260998.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KF73
      Conserved Domains (2) summary
      cd00029
      Location:708 → 754
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl12013
      Location:290 → 489
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    11. NM_001299526.1 → NP_001286455.1  Stac-like, isoform S [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286455.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFG4
      Conserved Domains (2) summary
      cd00029
      Location:708 → 754
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl12013
      Location:290 → 489
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    12. NM_001299524.1 → NP_001286453.1  Stac-like, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286453.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFF3
      Conserved Domains (1) summary
      cd00029
      Location:708 → 754
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    13. NM_001103852.3 → NP_001097322.1  Stac-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097322.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1EC92
      Conserved Domains (1) summary
      cd00029
      Location:708 → 754
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    14. NM_001382113.1 → NP_001369088.1  Stac-like, isoform W [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3Q7M2
      Conserved Domains (3) summary
      PHA03247
      Location:20 → 283
      PHA03247; large tegument protein UL36; Provisional
      cd20817
      Location:920 → 970
      C1_Stac; protein kinase C conserved region 1 (C1 domain) found in the SH3 and cysteine-rich domain-containing protein (Stac) family
      cl12013
      Location:502 → 701
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    15. NM_137192.2 → NP_611036.2  Stac-like, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611036.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4DHC0, Q29QR2
      Conserved Domains (1) summary
      cd00029
      Location:448 → 494
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    16. NM_001103854.4 → NP_001097324.1  Stac-like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097324.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYE7
      Conserved Domains (1) summary
      cd00029
      Location:45 → 91
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    17. NM_001103857.3 → NP_001097327.2  Stac-like, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097327.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYE9
      Conserved Domains (2) summary
      cd00029
      Location:107 → 153
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl17036
      Location:431 → 482
      SH3; Src Homology 3 domain superfamily

    18. NM_001103853.4 → NP_001097323.3  Stac-like, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097323.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYE8
      Conserved Domains (1) summary
      pfam00130
      Location:107 → 158
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KER3 A0A0B4KER3
    A0A0B4KEV7 A0A0B4KEV7
    A0A0B4KF73 A0A0B4KF73
    A0A0B4KFR2 A0A0B4KFR2
    A0A0B4KG20 A0A0B4KG20
    A0A0B4LF79 A0A0B4LF79
    A0A0B4LFF3 A0A0B4LFF3
    A0A0B4LFG4 A0A0B4LFG4
    A0A0B4LFI1 A0A0B4LFI1
    A0A0B4LGK0 A0A0B4LGK0
    A0A0C4DHC0 A0A0C4DHC0
    A0A6M3Q7M2 A0A6M3Q7M2
    A0A6M3QAK8 A0A6M3QAK8
    A8DYE4 A8DYE4
    A8DYE7 A8DYE7
    A8DYE8 A8DYE8
    A8DYE9 A8DYE9
    Q1EC92 Q1EC92

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